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    OSER1 oxidative stress responsive serine rich 1 [ Homo sapiens (human) ]

    Gene ID: 51526, updated on 14-Nov-2024

    Summary

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    Official Symbol
    OSER1provided by HGNC
    Official Full Name
    oxidative stress responsive serine rich 1provided by HGNC
    Primary source
    HGNC:HGNC:16105
    See related
    Ensembl:ENSG00000132823 AllianceGenome:HGNC:16105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Osr1; Perit1; HSPC207; C20orf111; dJ1183I21.1
    Summary
    Predicted to be involved in cellular response to hydrogen peroxide. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 25.7), bone marrow (RPKM 22.5) and 24 other tissues See more
    Orthologs
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    Genomic context

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    See OSER1 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44195939..44211810, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45930565..45949078, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42824579..42839411, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TOX high mobility group box family member 2 Neighboring gene RNA, 7SL, cytoplasmic 443, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42696545-42697061 Neighboring gene Sharpr-MPRA regulatory region 7745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42739928-42740441 Neighboring gene Sharpr-MPRA regulatory region 3924 Neighboring gene junctophilin 2 Neighboring gene uncharacterized LOC124904909 Neighboring gene JPH2 intron CAGE-defined T cell enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42795218-42795478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42806021-42806521 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:42809003-42809909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42810816-42811722 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:42832370-42833569 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42838821-42839440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12940 Neighboring gene OSER1 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42860439-42861068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42875650-42876448 Neighboring gene Sharpr-MPRA regulatory region 13448 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:42900885-42901394 Neighboring gene ganglioside induced differentiation associated protein 1 like 1 Neighboring gene Sharpr-MPRA regulatory region 2613 Neighboring gene uncharacterized LOC124904910

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oxidative stress-responsive serine-rich protein 1
    Names
    oxidative stress-responsive 1
    oxidative stress-responsive protein 1
    peroxide-inducible transcript 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016470.8 → NP_057554.4  oxidative stress-responsive serine-rich protein 1

      See identical proteins and their annotated locations for NP_057554.4

      Status: VALIDATED

      Source sequence(s)
      AL035447, BC064973, BF109349, BI462161
      Consensus CDS
      CCDS13327.1
      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Related
      ENSP00000255174.2, ENST00000255174.3
      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      44195939..44211810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027873.2 → XP_016883362.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    2. XM_011528854.4 → XP_011527156.1  oxidative stress-responsive serine-rich protein 1 isoform X2

      Conserved Domains (1) summary
      pfam05604
      Location:1 → 137
      DUF776; Protein of unknown function (DUF776)

    3. XM_047440191.1 → XP_047296147.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8

    4. XM_047440193.1 → XP_047296149.1  oxidative stress-responsive serine-rich protein 1 isoform X2

    5. XM_047440190.1 → XP_047296146.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8

    6. XM_047440192.1 → XP_047296148.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Related
      ENSP00000362061.1, ENST00000372970.6

    7. XM_011528853.4 → XP_011527155.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011527155.1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      45930565..45949078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323485.1 → XP_054179460.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    2. XM_054323488.1 → XP_054179463.1  oxidative stress-responsive serine-rich protein 1 isoform X2

    3. XM_054323486.1 → XP_054179461.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    4. XM_054323484.1 → XP_054179459.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    5. XM_054323487.1 → XP_054179462.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    6. XM_054323489.1 → XP_054179464.1  oxidative stress-responsive serine-rich protein 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NX31.2 GenPept UniProtKB/Swiss-Prot:Q9NX31

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