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    MGAT1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [ Homo sapiens (human) ]

    Gene ID: 4245, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MGAT1provided by HGNC
    Official Full Name
    alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:7044
    See related
    Ensembl:ENSG00000131446 MIM:160995; AllianceGenome:HGNC:7044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GnTI; MGAT; GLCT1; GLYT1; GNT-1; GNT-I; GLCNAC-TI
    Summary
    There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 30.2), spleen (RPKM 29.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MGAT1 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180784780..180815616, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181341132..181371969, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180211780..180242616, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 17, pseudogene Neighboring gene olfactory receptor family 2 subfamily Y member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212035-180212946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212947-180213857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180224505-180225006 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr5:180229118-180229825 and GRCh37_chr5:180229826-180230532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180231240-180231945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23771 Neighboring gene Sharpr-MPRA regulatory region 14850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16777 Neighboring gene long intergenic non-protein coding RNA 847 Neighboring gene ZFP62 zinc finger protein Neighboring gene Sharpr-MPRA regulatory region 9005 Neighboring gene hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180288413-180289319 Neighboring gene uncharacterized LOC124901155

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population. Tapia-Rivera JC, et al. Med Clin (Barc), 2017 Feb 23. PMID 27871764
    2. Elucidating the multifaceted role of MGAT1 in hepatocellular carcinoma: integrative single-cell and spatial transcriptomics reveal novel therapeutic insights. Li Y, et al. Front Immunol, 2024. PMID 39081317, Free PMC Article
    3. Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene. Hull E, et al. Biochem Biophys Res Commun, 1991 Apr 30. PMID 1827260
    4. Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis. Yip B, et al. Biochem J, 1997 Jan 15. PMID 9020882, Free PMC Article
    5. Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121. Saribas AS, et al. Biochem Biophys Res Commun, 2007 Oct 19. PMID 17716624

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elucidating the multifaceted role of MGAT1 in hepatocellular carcinoma: integrative single-cell and spatial transcriptomics reveal novel therapeutic insights.
      Title: Elucidating the multifaceted role of MGAT1 in hepatocellular carcinoma: integrative single-cell and spatial transcriptomics reveal novel therapeutic insights.
    2. MicroRNA miR-331-3p suppresses osteosarcoma progression via the Bcl-2/Bax and Wnt/beta-Catenin signaling pathways and the epithelial-mesenchymal transition by targeting N-acetylglucosaminyltransferase I (MGAT1).
      Title: MicroRNA miR-331-3p suppresses osteosarcoma progression via the Bcl-2/Bax and Wnt/β-Catenin signaling pathways and the epithelial-mesenchymal transition by targeting N-acetylglucosaminyltransferase I (MGAT1).
    3. Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.
      Title: Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.
    4. MGAT1 promotes complex N-glycosylation of glucose transporter 1 (Glut1) and increases Glut1 protein levels. In summary, our findings indicate that MGAT1 is highly expressed in glioblastoma and promotes glioma cells at least partly through upregulation of Glut1 protein.
      Title: N-acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1.
    5. MGAT1 activity may play a role in regulating basal adipocyte FFA retention
      Title: Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.
    6. In this study we showed that the activation of Wnt/beta-catenin pathway culminates in the upregulation of MGAT1 enzyme both at transcriptional and post-transcriptional levels. We also showed that overexpression of the beta-catenin gene (CTNNB1) increased the promoter activity of MGAT1.
      Title: MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway.
    7. The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population.
      Title: The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population.
    8. MGAT1 is downregulated in peripheral blood mononuclear cells of galactosaemia patients.
      Title: Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.
    9. The authors show here that the luminal domain of GnT1IP-L contains its MGAT1 inhibitory activity.
      Title: GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain.
    10. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).
      Title: UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    EBI GWAS Catalog
    Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env trimers expressing in the absence of GNTI have a mass of 394-390 kDa compared to the parent trimers of about 420 kDa. HIV-1 produced in the absence of GNTI is infectious PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral protein processing TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular vesicle HDA PubMed 
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Names
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
    glcNAc-T I
    mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    NP_001108089.1
    NP_001108090.1
    NP_001108091.1
    NP_001108092.1
    NP_001351306.1
    NP_001351308.1
    NP_001351309.1
    NP_001351310.1
    NP_001351311.1
    NP_001351312.1
    NP_001351313.1
    NP_001351314.1
    NP_001351315.1
    NP_001351316.1
    NP_001351317.1
    NP_001351318.1
    NP_001351319.1
    NP_001351320.1
    NP_001351321.1
    NP_001351322.1
    NP_001351323.1
    NP_001351324.1
    NP_002397.2
    XP_047273177.1
    XP_047273178.1
    XP_047273179.1
    XP_047273180.1
    XP_047273181.1
    XP_047273182.1
    XP_047273183.1
    XP_047273184.1
    XP_047273185.1
    XP_054208621.1
    XP_054208622.1
    XP_054208623.1
    XP_054208624.1
    XP_054208625.1
    XP_054208626.1
    XP_054208627.1
    XP_054208628.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032928.2 RefSeqGene

      Range
      17847..35873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001114617.2 → NP_001108089.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001108089.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, AK094130, CA426780, DB270226, M55621
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Related
      ENSP00000377010.3, ENST00000393340.7
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    2. NM_001114618.1 → NP_001108090.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001108090.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AK094130, BG337235, CA426780, M55621
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Related
      ENSP00000404718.2, ENST00000446023.6
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    3. NM_001114619.1 → NP_001108091.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001108091.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      CA426780, DC383950, M55621
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    4. NM_001114620.1 → NP_001108092.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001108092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      CA426780, DC383950, M55621
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Related
      ENSP00000402838.2, ENST00000427865.2
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    5. NM_001364377.2 → NP_001351306.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    6. NM_001364379.2 → NP_001351308.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    7. NM_001364380.2 → NP_001351309.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    8. NM_001364381.2 → NP_001351310.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, AK057194
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Related
      ENSP00000332073.3, ENST00000333055.8
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    9. NM_001364382.2 → NP_001351311.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA471492
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    10. NM_001364383.2 → NP_001351312.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, BP300306
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    11. NM_001364384.2 → NP_001351313.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    12. NM_001364385.2 → NP_001351314.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA273577
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    13. NM_001364386.2 → NP_001351315.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    14. NM_001364387.2 → NP_001351316.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    15. NM_001364388.2 → NP_001351317.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA292271
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    16. NM_001364389.2 → NP_001351318.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA440728
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    17. NM_001364390.2 → NP_001351319.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA467596
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    18. NM_001364391.2 → NP_001351320.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA997500
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    19. NM_001364392.2 → NP_001351321.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DB050338
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    20. NM_001364393.2 → NP_001351322.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA030335
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    21. NM_001364394.2 → NP_001351323.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, DA028514
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    22. NM_001364395.2 → NP_001351324.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    23. NM_002406.4 → NP_002397.2  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_002397.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
      Source sequence(s)
      AC022413, CA426780, CN409895, M55621
      Consensus CDS
      CCDS4458.1
      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3
      UniProtKB/TrEMBL
      B3KQ18
      Related
      ENSP00000311888.4, ENST00000307826.5
      Conserved Domains (1) summary
      pfam03071
      Location:12 → 444
      GNT-I; GNT-I family

    RNA

    1. NR_157150.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
      Source sequence(s)
      AC022413, AV717693

    2. NR_157151.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
      Source sequence(s)
      AC022413

    3. NR_157152.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) uses an alternate 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
      Source sequence(s)
      AC022413

    4. NR_157153.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
      Source sequence(s)
      AC022413

    5. NR_157154.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
      Source sequence(s)
      AC022413, AI188463

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      180784780..180815616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417229.1 → XP_047273185.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    2. XM_047417228.1 → XP_047273184.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    3. XM_047417222.1 → XP_047273178.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    4. XM_047417221.1 → XP_047273177.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    5. XM_047417227.1 → XP_047273183.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    6. XM_047417223.1 → XP_047273179.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    7. XM_047417225.1 → XP_047273181.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    8. XM_047417226.1 → XP_047273182.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    9. XM_047417224.1 → XP_047273180.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A8K404, B3KRU8, D3DWR1, P26572, Q6IBE3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      181341132..181371969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352653.1 → XP_054208628.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    2. XM_054352652.1 → XP_054208627.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    3. XM_054352647.1 → XP_054208622.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    4. XM_054352646.1 → XP_054208621.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    5. XM_054352648.1 → XP_054208623.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    6. XM_054352651.1 → XP_054208626.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    7. XM_054352649.1 → XP_054208624.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    8. XM_054352650.1 → XP_054208625.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26572.2 GenPept UniProtKB/Swiss-Prot:P26572

    Gene LinkOut

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