Igtp interferon gamma induced GTPase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igtpprovided by MGI
Official Full Name: interferon gamma induced GTPaseprovided by MGI
Primary source: MGI:MGI:107729
See related: Ensembl:ENSMUSG00000078853 AllianceGenome:MGI:107729
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Irgm3
Summary: Enables GTPase activity. Involved in several processes, including defense response to other organism; negative regulation of PERK-mediated unfolded protein response; and positive regulation of autophagosome maturation. Acts upstream of or within cellular response to interferon-beta. Located in cytosol. Is active in endoplasmic reticulum. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in liver E18 (RPKM 26.0), liver adult (RPKM 21.2) and 22 other tissues See more
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Genomic context

Location:: 11 B1.3; 11 36.01 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (58090382..58098418)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (58199556..58207592)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

protection from experimental cerebral malaria pathology in Irgm3-/- mice occurs due to impaired generation of CD8+ effector function. This defect is nonintrinsic to CD8+ T cells.
Title: IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.
the paralogous IRGM proteins Irgm1 and Irgm3 fail to robustly associate with "non-self" PVs containing either the bacterial pathogen Chlamydia trachomatis or the protozoan pathogen Toxoplasma gondii
Title: IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.
IRGM proteins indirectly modulate the localization of GBP2 through a distinct mechanism from that through which they regulate IRG protein localization
Title: Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.
Data show that hyperproliferation, self-renewal, and autophagy defects in Irgm1(-/-) HSCs were normalized in double-knockout Irgm1(-/-)Ifngr1(-/-) and Irgm1(-/-)Stat1(-/-), and the defects were abolished in Irgm1(-/-)Irgm3(-/-) double-knockout.
Title: Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
IFN-gamma-inducible signaling has pleiotropic effects on immune defense and revealing that p47 GTPases function differentially depending on invading pathogen species.
Title: IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection.
Irgm3 is stimulated by interferon-gamma, and functions to counter the effects of Irgm1.
Title: Balance of Irgm protein activities determines IFN-gamma-induced host defense.
Immunity-related GTPase (IRG) family member Irgm3 is required for the ability of in vivo primed macrophages to restrain the growth of Toxoplasma gondii and to destroy the parasite's intracellular niche.
Title: Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages.
Vacuolar disruption in T. gondii infected murine astrocytes was found to be dependent upon IFN-gamma-inducible GTP-binding protein
Title: The gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytes.
Focal adhesion kinase is phosphorylated in response to interferon-gamma-inducible GTPase expression.
Title: Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.
Differential induction by various gram-negative lipopolysaccharides was myeloid differentiation factor 88 (MyD88)-independent
Title: Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igtp (e-PCR), detects polymorphism
- UniSTS:506998

AW558444 (e-PCR)
- UniSTS:180210

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BH3 domain binding	ISO Inferred from Sequence Orthology more info
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CAMKK-AMPK signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in CD8-positive, alpha-beta T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in cytolysis in another organism	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of PERK-mediated unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of xenophagy	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein lipidation involved in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to vacuole involved in autophagy	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein complex stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: immunity-related GTPase family M protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018738.4 → NP_061208.3 immunity-related GTPase family M protein 3

See identical proteins and their annotated locations for NP_061208.3

Status: VALIDATED

Source sequence(s)

AA275064, AK002843, AL928857

Consensus CDS

CCDS24725.1

UniProtKB/Swiss-Prot

J7PDL1, Q8C2M8, Q9DCE9

UniProtKB/TrEMBL

Q811M6

Related

ENSMUSP00000047356.5, ENSMUST00000035266.11

Conserved Domains (2) summary

cd04104
Location:84 → 277

p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1

pfam05049
Location:51 → 412

IIGP; Interferon-inducible GTPase (IIGP)