PARP15 poly(ADP-ribose) polymerase family member 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PARP15provided by HGNC
Official Full Name: poly(ADP-ribose) polymerase family member 15provided by HGNC
Primary source: HGNC:HGNC:26876
See related: Ensembl:ENSG00000173200 MIM:612066; AllianceGenome:HGNC:26876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAL3; ARTD7; pART7
Summary: Enables NAD+ binding activity; NAD+-protein poly-ADP-ribosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and protein poly-ADP-ribosylation. Predicted to be active in cytoplasm and nucleus. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen (RPKM 9.7), lymph node (RPKM 8.3) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 3q21.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (122577650..122639047)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (125296890..125358300)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (122296497..122357894)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The current study investigated the possible association between PARP15 single-nucleotide polymorphisms and the risk of acute myeloid leukemia (AML). The results from a Cox regression analysis for overall survival revealed that two polymorphisms associated with increased overall survival and the signal for rs17208928 was retained after correcting for multiple tests. rs17208928 showed a significant association with survival
Title: Genetic Association of PARP15 Polymorphisms with Clinical Outcome of Acute Myeloid Leukemia in a Korean Population.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
BAL macro domains repress transcription when tethered to a promoter; BAL2 and BAL3, but not BAL1, exhibit PARP activity
Title: B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A mega-analysis of genome-wide association studies for major depressive disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of chronic periodontitis in a general German population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S3014 (e-PCR)
- UniSTS:152118

D11S3017 (e-PCR)
- UniSTS:152121

D11S2766 (e-PCR)
- UniSTS:151969

NoName (e-PCR)
- UniSTS:62643

NoName (e-PCR)
- UniSTS:485365

Clone Names

FLJ40196, FLJ40597, MGC126750, MGC126752

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NAD+ binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein poly-ADP-ribosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP15

Names: ADP-ribosyltransferase diphtheria toxin-like 7; B-aggressive lymphoma 3; B-aggressive lymphoma protein 3; PARP-15; poly [ADP-ribose] polymerase 15

NP_001106995.1

EC 2.4.2.30

NP_001295249.1

EC 2.4.2.30

NP_001295250.1

EC 2.4.2.30

NP_689828.1

EC 2.4.2.30

XP_005247216.1

EC 2.4.2.30

XP_005247217.1

EC 2.4.2.30

XP_011510777.1

EC 2.4.2.30

XP_011510778.1

EC 2.4.2.30

XP_011510779.1

EC 2.4.2.30

XP_011510781.1

EC 2.4.2.30

XP_011510782.1

EC 2.4.2.30

XP_016861280.1

EC 2.4.2.30

XP_016861281.1

EC 2.4.2.30

XP_047303536.1

EC 2.4.2.30

XP_047303538.1

EC 2.4.2.30

XP_047303539.1

EC 2.4.2.30

XP_047303540.1

EC 2.4.2.30

XP_054201441.1

EC 2.4.2.30

XP_054201442.1

EC 2.4.2.30

XP_054201443.1

EC 2.4.2.30

XP_054201444.1

EC 2.4.2.30

XP_054201445.1

EC 2.4.2.30

XP_054201446.1

EC 2.4.2.30

XP_054201447.1

EC 2.4.2.30

XP_054201448.1

EC 2.4.2.30

XP_054201449.1

EC 2.4.2.30

XP_054201450.1

EC 2.4.2.30

XP_054201451.1

EC 2.4.2.30

XP_054201452.1

EC 2.4.2.30

XP_054201453.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113523.3 → NP_001106995.1 protein mono-ADP-ribosyltransferase PARP15 isoform 1

See identical proteins and their annotated locations for NP_001106995.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC092908, AK097916, AK309863, BC101701, BX647656, DQ063586

Consensus CDS

CCDS46893.1

UniProtKB/Swiss-Prot

J3KR47, Q460N3, Q8N1K3

Related

ENSP00000417214.2, ENST00000464300.7

Conserved Domains (3) summary

cd01439
Location:556 → 676

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:297 → 463

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cl00019
Location:88 → 263

Macro_SF; macrodomain superfamily
NM_001308320.2 → NP_001295249.1 protein mono-ADP-ribosyltransferase PARP15 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three alternate in-frame coding exons and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter compared to isoform 1.

Source sequence(s)

AC092908, AK097916, BX647656

Consensus CDS

CCDS77803.1

UniProtKB/TrEMBL

C9J7L3

Related

ENSP00000417785.1, ENST00000483793.5

Conserved Domains (3) summary

cd01439
Location:361 → 481

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam00644
Location:304 → 481

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl00019
Location:181 → 287

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
NM_001308321.2 → NP_001295250.1 protein mono-ADP-ribosyltransferase PARP15 isoform 4

See identical proteins and their annotated locations for NP_001295250.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, resulting in the presence of a novel 5' coding region and start codon, compared to variant 1. The encoded isoform (4) has a shorter distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC092908, BC143573, BX647656

Consensus CDS

CCDS77804.1

UniProtKB/TrEMBL

B3KUL9, B7ZL48

Related

ENSP00000419488.1, ENST00000493645.1

Conserved Domains (3) summary

cd01439
Location:253 → 373

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam00644
Location:196 → 373

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl00019
Location:70 → 179

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
NM_152615.3 → NP_689828.1 protein mono-ADP-ribosyltransferase PARP15 isoform 2

See identical proteins and their annotated locations for NP_689828.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in the presence of a novel 5' coding region and start codon. The encoded isoform (2) has a shorter distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC092908, AK097916, BC101701, BX647656

Consensus CDS

CCDS3016.1

UniProtKB/TrEMBL

B3KUL9

Related

ENSP00000308436.4, ENST00000310366.8

Conserved Domains (2) summary

cd01439
Location:322 → 442

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:70 → 197

Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

122577650..122639047

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005247159.5 → XP_005247216.1 protein mono-ADP-ribosyltransferase PARP15 isoform X3

Conserved Domains (2) summary

smart00506
Location:90 → 223

A1pp; Appr-1"-p processing enzyme

cd01439
Location:487 → 607

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_011512476.4 → XP_011510778.1 protein mono-ADP-ribosyltransferase PARP15 isoform X2

Conserved Domains (2) summary

smart00506
Location:90 → 223

A1pp; Appr-1"-p processing enzyme

cd01439
Location:506 → 626

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_047447580.1 → XP_047303536.1 protein mono-ADP-ribosyltransferase PARP15 isoform X5
XM_005247160.5 → XP_005247217.1 protein mono-ADP-ribosyltransferase PARP15 isoform X4

Conserved Domains (3) summary

smart00506
Location:230 → 346

A1pp; Appr-1"-p processing enzyme

cd01439
Location:480 → 600

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cl00019
Location:107 → 179

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
XM_017005791.3 → XP_016861280.1 protein mono-ADP-ribosyltransferase PARP15 isoform X7

Conserved Domains (3) summary

smart00506
Location:230 → 336

A1pp; Appr-1"-p processing enzyme

cd01439
Location:411 → 531

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cl00019
Location:107 → 179

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
XM_011512477.4 → XP_011510779.1 protein mono-ADP-ribosyltransferase PARP15 isoform X6

Conserved Domains (3) summary

smart00506
Location:181 → 296

A1pp; Appr-1"-p processing enzyme

cd01439
Location:430 → 550

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cl00019
Location:107 → 179

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
XM_011512475.4 → XP_011510777.1 protein mono-ADP-ribosyltransferase PARP15 isoform X1

Conserved Domains (3) summary

smart00506
Location:266 → 382

A1pp; Appr-1"-p processing enzyme

cd01439
Location:516 → 636

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam01661
Location:67 → 176

Macro; Macro domain
XM_011512480.4 → XP_011510782.1 protein mono-ADP-ribosyltransferase PARP15 isoform X11

Conserved Domains (2) summary

smart00506
Location:90 → 223

A1pp; Appr-1"-p processing enzyme

cl00019
Location:306 → 350

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
XM_047447582.1 → XP_047303538.1 protein mono-ADP-ribosyltransferase PARP15 isoform X8
XM_011512479.4 → XP_011510781.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9

See identical proteins and their annotated locations for XP_011510781.1

UniProtKB/TrEMBL

B3KUL9

Conserved Domains (2) summary

smart00506
Location:53 → 169

A1pp; Appr-1"-p processing enzyme

cd01439
Location:303 → 423

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_017005792.3 → XP_016861281.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9

UniProtKB/TrEMBL

B3KUL9

Conserved Domains (2) summary

smart00506
Location:53 → 169

A1pp; Appr-1"-p processing enzyme

cd01439
Location:303 → 423

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_047447584.1 → XP_047303540.1 protein mono-ADP-ribosyltransferase PARP15 isoform X10
XM_047447583.1 → XP_047303539.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

125296890..125358300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054345468.1 → XP_054201443.1 protein mono-ADP-ribosyltransferase PARP15 isoform X3
XM_054345467.1 → XP_054201442.1 protein mono-ADP-ribosyltransferase PARP15 isoform X2
XM_054345470.1 → XP_054201445.1 protein mono-ADP-ribosyltransferase PARP15 isoform X5
XM_054345469.1 → XP_054201444.1 protein mono-ADP-ribosyltransferase PARP15 isoform X4
XM_054345472.1 → XP_054201447.1 protein mono-ADP-ribosyltransferase PARP15 isoform X7
XM_054345471.1 → XP_054201446.1 protein mono-ADP-ribosyltransferase PARP15 isoform X6
XM_054345466.1 → XP_054201441.1 protein mono-ADP-ribosyltransferase PARP15 isoform X1
XM_054345478.1 → XP_054201453.1 protein mono-ADP-ribosyltransferase PARP15 isoform X11
XM_054345473.1 → XP_054201448.1 protein mono-ADP-ribosyltransferase PARP15 isoform X8
XM_054345476.1 → XP_054201451.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9
XM_054345474.1 → XP_054201449.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9
XM_054345477.1 → XP_054201452.1 protein mono-ADP-ribosyltransferase PARP15 isoform X10
XM_054345475.1 → XP_054201450.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9