Sp6 Sp6 transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sp6provided by RGD
Official Full Name: Sp6 transcription factorprovided by RGD
Primary source: RGD:1306768
See related: EnsemblRapid:ENSRNOG00000023551 AllianceGenome:RGD:1306768
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epithelial to mesenchymal transition; odontogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of odontogenesis. Located in cytosol and nucleus. Used to study amelogenesis imperfecta. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1K. Orthologous to human SP6 (Sp6 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 6.0), Thymus (RPKM 4.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (82501957..82506138)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (82005518..82009699)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (84950751..84961368)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sp6 positively regulates Rock1 transcription by direct binding to the Rock1 promoter region from -206 to -150, which functionally distinct from Sp1
Title: Sp6 regulation of Rock1 promoter activity in dental epithelial cells.
Morphological differentiation and metabolism of the iron-containing pigment in ameloblasts are independently regulated during amelogenesis by means of ectopic SP6 expression.
Title: Dissection of morphological and metabolic differentiation of ameloblasts via ectopic SP6 expression.
Findings suggest that the regulation of SP6 protein stability is one of the crucial steps in amelogenesis.
Title: Possible linkage of SP6 transcriptional activity with amelogenesis by protein stabilization.
Sp6 promotes amelogenesis through inhibition of follistatin gene expression.
Title: Sp6 downregulation of follistatin gene expression in ameloblasts.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor Sp6

Names: trans-acting transcription factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108833.1 → NP_001102303.1 transcription factor Sp6

See identical proteins and their annotated locations for NP_001102303.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HII2, D3ZT88

Related

ENSRNOP00000030832.4, ENSRNOT00000038572.6

Conserved Domains (4) summary

COG5048
Location:261 → 336

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:259 → 278

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:314 → 336

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:300 → 323

zf-H2C2_2; Zinc-finger double domain