Eif3l eukaryotic translation initiation factor 3, subunit L [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif3lprovided by MGI
Official Full Name: eukaryotic translation initiation factor 3, subunit Lprovided by MGI
Primary source: MGI:MGI:2386251
See related: Ensembl:ENSMUSG00000033047 AllianceGenome:MGI:2386251
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAF67; D15N1e; Eif3ip; Eif3eip; HSP-66Y; Eif3s6ip; 0610011H21Rik
Summary: Contributes to translation initiation factor activity. Involved in translational initiation. Located in fibrillar center and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. Is active in synapse. Is expressed in thymus primordium. Orthologous to human EIF3L (eukaryotic translation initiation factor 3 subunit L). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 103.9), ovary adult (RPKM 96.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78959423..78978600)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79075223..79094400)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in viral translational termination-reinitiation	IEA Inferred from Electronic Annotation more info
involved_in viral translational termination-reinitiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit L

Names: 66 kDa tyrosine-rich heat shock protein; 67 kDa polymerase-associated factor; eukaryotic translation initiation factor 3 subunit 6-interacting protein; eukaryotic translation initiation factor 3 subunit E-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.