SLC51B SLC51 subunit beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC51Bprovided by HGNC
Official Full Name: SLC51 subunit betaprovided by HGNC
Primary source: HGNC:HGNC:29956
See related: Ensembl:ENSG00000186198 MIM:612085; AllianceGenome:HGNC:29956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OSTB; PBAM2; OSTBETA; SLC51A1BP
Summary: Predicted to enable protein heterodimerization activity. Involved in bile acid secretion. Located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine (RPKM 39.7), duodenum (RPKM 31.2) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q22.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (65045387..65053397)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (62854823..62862823)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (65337725..65345735)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells.
Title: HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells.
Study found lower organic solute transporter beta (OSTbeta) expression in colon cancer tissues compared with adjacent normal tissues and revealed the epigenetic mechanisms of it and proved that p300 controls OSTbeta expression through modulating H3K27Ac state at OSTbeta promoter region and hence causes low expression of OSTbeta in colorectal cancer.
Title: Epigenetic Mechanisms Underlying Organic Solute Transporter β Repression in Colorectal Cancer.
Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting.
Title: A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.
Hepatic OSTalpha-OSTbeta expression is induced by hypoxia.
Title: The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.
OSTbeta is a target of RARalpha-mediated (by binding to DR5 response element) gene regulation pathways
Title: A novel RARα/CAR-mediated mechanism for regulation of human organic solute transporter-β gene expression.
Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.
Title: β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.
The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues.
Title: Pleiotropic functions of the organic solute transporter Ostα-Ostβ.
OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis
Title: Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
interaction of solute transporter beta with human organic solute transporter alpha.
Title: N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.
The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers
Title: Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Bile acid malabsorption, primary, 2 MedGen: C5561962 OMIM: 619481 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15S1507 (e-PCR), detects polymorphism
- UniSTS:38703

D15S953 (e-PCR)
- UniSTS:44341

RH98169 (e-PCR)
- UniSTS:86353

NoName (e-PCR)
- UniSTS:484197

RH48386 (e-PCR)
- UniSTS:80049

D15S619E (e-PCR)
- UniSTS:18610

Clone Names

FLJ26090, MGC118959, MGC118960, MGC118961

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in bile acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid secretion	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of protein exit from endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: organic solute transporter subunit beta

Names: OST-beta; SLC51A1 binding protein; organic solute transporter beta subunit; solute carrier family 51 beta subunit; solute carrier family 51 subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.