Idh1 isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Idh1provided by MGI
Official Full Name: isocitrate dehydrogenase 1 (NADP+), solubleprovided by MGI
Primary source: MGI:MGI:96413
See related: Ensembl:ENSMUSG00000025950 AllianceGenome:MGI:96413
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Id-1; Idpc; Idh-1; E030024J03Rik
Summary: Enables isocitrate dehydrogenase (NADP+) activity. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 104.0), CNS E18 (RPKM 83.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2- C3; 1 32.91 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (65197775..65225638, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (65158616..65186479, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity.
Title: Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity.
Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
Title: Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Title: IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
Title: Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
Title: Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.
Title: HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
Title: Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
Mutant IDH Inhibits IFNgamma-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
Title: Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair.
Title: Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair.
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/alpha-KG-mediated glycolysis.
Title: Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (1)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140721 (e-PCR)
- UniSTS:222787

AI314845 (e-PCR)
- UniSTS:158802

NoName (e-PCR)
- UniSTS:224346

PMC55400P2 (e-PCR)
- UniSTS:273339

AI788952 (e-PCR)
- UniSTS:178404

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables isocitrate dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in female gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyoxylate cycle	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isocitrate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of phospholipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to steroid hormone	IEA Inferred from Electronic Annotation more info
involved_in response to steroid hormone	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isocitrate dehydrogenase [NADP] cytoplasmic

Names: IDH; IDP; NADP(+)-specific ICDH; cytosolic NADP-isocitrate dehydrogenase; oxalosuccinate decarboxylase

NP_001104790.1

EC 1.1.1.42

NP_034627.3

EC 1.1.1.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111320.1 → NP_001104790.1 isocitrate dehydrogenase [NADP] cytoplasmic

See identical proteins and their annotated locations for NP_001104790.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK167158, BY787507, CF379827, CF950262

Consensus CDS

CCDS15016.1

UniProtKB/Swiss-Prot

O88844, Q3UAV7

UniProtKB/TrEMBL

Q3TJ51, Q5HZJ8

Related

ENSMUSP00000127307.2, ENSMUST00000169032.8

Conserved Domains (1) summary

PTZ00435
Location:1 → 411

PTZ00435; isocitrate dehydrogenase; Provisional
NM_010497.3 → NP_034627.3 isocitrate dehydrogenase [NADP] cytoplasmic

See identical proteins and their annotated locations for NP_034627.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK167158, BB868400, CF379827

Consensus CDS

CCDS15016.1

UniProtKB/Swiss-Prot

O88844, Q3UAV7

UniProtKB/TrEMBL

Q3TJ51, Q5HZJ8

Related

ENSMUSP00000095316.5, ENSMUST00000097709.11

Conserved Domains (1) summary

PTZ00435
Location:1 → 411

PTZ00435; isocitrate dehydrogenase; Provisional