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    Brms1l breast cancer metastasis-suppressor 1-like [ Mus musculus (house mouse) ]

    Gene ID: 52592, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Brms1lprovided by MGI
    Official Full Name
    breast cancer metastasis-suppressor 1-likeprovided by MGI
    Primary source
    MGI:MGI:1196337
    See related
    Ensembl:ENSMUSG00000012076 AllianceGenome:MGI:1196337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BRMS1; D12Ertd407e; 0710008O11Rik
    Summary
    Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of Sin3-type complex. Orthologous to human BRMS1L (BRMS1 like transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 23.2), frontal lobe adult (RPKM 20.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Brms1l in Genome Data Viewer
    Location:
    12 C1; 12 24.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55883109..55916521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55836324..55869736)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein, alpha subunit 1 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56937027-56937210 Neighboring gene STARR-seq mESC enhancer starr_32198 Neighboring gene predicted gene, 22296 Neighboring gene predicted gene, 53722

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. β-catenin regulates GnRH-induced FSHβ gene expression. Wang Q, et al. Mol Endocrinol, 2013 Feb. PMID 23211523, Free PMC Article
    2. Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. Streubel G, et al. EMBO J, 2017 Aug 1. PMID 28554894, Free PMC Article
    3. Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex. Smith KT, et al. Mol Cell Proteomics, 2012 Dec. PMID 22984288, Free PMC Article
    4. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Zhang Y, et al. Mol Cell, 1998 Jun. PMID 9651585
    5. Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. Muñoz IM, et al. J Biol Chem, 2012 Sep 21. PMID 22865885, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast cancer metastasis-suppressor 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037756.3 → NP_001032845.1  breast cancer metastasis-suppressor 1-like protein

      See identical proteins and their annotated locations for NP_001032845.1

      Status: VALIDATED

      Source sequence(s)
      AK155742, BC034885
      Consensus CDS
      CCDS36453.1
      UniProtKB/Swiss-Prot
      Q3U1T3, Q8JZX8
      Related
      ENSMUSP00000082500.5, ENSMUST00000059250.8
      Conserved Domains (1) summary
      pfam08598
      Location:61 → 179
      Sds3; Sds3-like

    RNA

    1. NR_155205.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159624, CR974464

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55883109..55916521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_381530.4 RNA Sequence

    2. XR_004937525.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027867.2: Suppressed sequence

      Description
      NM_027867.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1T3.1 GenPept UniProtKB/Swiss-Prot:Q3U1T3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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