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    Med12l mediator complex subunit 12-like [ Mus musculus (house mouse) ]

    Gene ID: 329650, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Med12lprovided by MGI
    Official Full Name
    mediator complex subunit 12-likeprovided by MGI
    Primary source
    MGI:MGI:2139916
    See related
    Ensembl:ENSMUSG00000056476 AllianceGenome:MGI:2139916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRALPUSH; A130035F20; A630079M02
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Orthologous to human MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 4.7), CNS E18 (RPKM 3.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med12l in Genome Data Viewer
    Location:
    3 D; 3 28.89 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58912820..59225867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59005419..59318446)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 6 Neighboring gene predicted gene, 25572 Neighboring gene STARR-positive B cell enhancer ABC_E6054 Neighboring gene STARR-seq mESC enhancer starr_07762 Neighboring gene STARR-seq mESC enhancer starr_07763 Neighboring gene G protein-coupled receptor 171 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene purinergic receptor P2Y, G-protein coupled, 14 Neighboring gene STARR-seq mESC enhancer starr_07764 Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene nuclear encoded tRNA valine 1 (anticodon CAC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. Vogl MR, et al. J Neurosci, 2013 Apr 10. PMID 23575864, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 12-like protein
    Names
    mediator complex subunit 12-like protein
    mediator of RNA polymerase II transcription, subunit 12 homolog-like
    no opposite paired repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177855.3 → NP_808523.2  mediator of RNA polymerase II transcription subunit 12-like protein

      Status: VALIDATED

      Source sequence(s)
      AA409741, AC122038, AK018323, AK037666, AK047743, BB646790, BP757618, BP757619, CA316095, CA318113, CB520516, CK638338
      Consensus CDS
      CCDS79912.1
      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      UniProtKB/TrEMBL
      A0A0G2JET8
      Related
      ENSMUSP00000142903.2, ENSMUST00000199659.5
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1838 → 2062
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283 → 765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      58912820..59225867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252646.2 → XP_030108506.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 2073
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    2. XM_036163137.1 → XP_036019030.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1814 → 2040
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 741
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    3. XM_017319618.3 → XP_017175107.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X11

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 1931
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    4. XM_006501593.5 → XP_006501656.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 1931
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    5. XM_006501592.5 → XP_006501655.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 2068
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    6. XM_006501589.5 → XP_006501652.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 2073
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    7. XM_006501591.5 → XP_006501654.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 2068
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    8. XM_030252645.2 → XP_030108505.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 2073
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    9. XM_030252647.2 → XP_030108507.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      UniProtKB/TrEMBL
      A0A0G2JET8
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1838 → 2062
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283 → 765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    10. XM_006501587.5 → XP_006501650.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1844 → 2068
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    11. XM_006501586.5 → XP_006501649.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1848 → 2072
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    12. XM_006501588.5 → XP_006501651.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1814 → 2040
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 741
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    13. XM_030252649.2 → XP_030108509.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1803 → 2027
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283 → 730
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    14. XM_030252648.1 → XP_030108508.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1814 → 2040
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 741
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    RNA

    1. XR_004941335.1 RNA Sequence

    2. XR_004941334.1 RNA Sequence

    3. XR_003954333.2 RNA Sequence

    4. XR_375531.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQM9.2 GenPept UniProtKB/Swiss-Prot:Q8BQM9

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