Zbtb43 zinc finger and BTB domain containing 43 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb43provided by MGI
Official Full Name: zinc finger and BTB domain containing 43provided by MGI
Primary source: MGI:MGI:1919084
See related: Ensembl:ENSMUSG00000026788 AllianceGenome:MGI:1919084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp297b; mKIAA0414; 1700010E06Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase III general transcription initiation factor binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human ZBTB43 (zinc finger and BTB domain containing 43). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 5.6), CNS E18 (RPKM 5.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (33340299..33358592, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (33450287..33468581, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III general transcription initiation factor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 43

Names: ortholog of zinc finger protein 297B ZNF297B; zinc finger protein 297B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025594.1 → NP_001020765.1 zinc finger and BTB domain-containing protein 43 isoform b

See identical proteins and their annotated locations for NP_001020765.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).

Source sequence(s)

AL929212, BC043117

Consensus CDS

CCDS15943.1

UniProtKB/Swiss-Prot

Q9DAI4

UniProtKB/TrEMBL

Q3UGQ6

Related

ENSMUSP00000028125.6, ENSMUST00000028125.12

Conserved Domains (3) summary

sd00017
Location:376 → 394

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18227
Location:8 → 128

BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)

pfam13465
Location:414 → 437

zf-H2C2_2; Zinc-finger double domain
NM_001355610.1 → NP_001342539.1 zinc finger and BTB domain-containing protein 43 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AL929212, DV650463

Consensus CDS

CCDS15942.1

UniProtKB/TrEMBL

G3X9N4, Q3UGQ6

Conserved Domains (3) summary

sd00017
Location:413 → 431

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:60 → 160

BTB; BTB/POZ domain

pfam13465
Location:451 → 474

zf-H2C2_2; Zinc-finger double domain
NM_001355611.1 → NP_001342540.1 zinc finger and BTB domain-containing protein 43 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).

Source sequence(s)

AL929212

Consensus CDS

CCDS15943.1

UniProtKB/Swiss-Prot

Q9DAI4

UniProtKB/TrEMBL

Q3UGQ6

Conserved Domains (3) summary

sd00017
Location:376 → 394

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18227
Location:8 → 128

BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)

pfam13465
Location:414 → 437

zf-H2C2_2; Zinc-finger double domain
NM_001355612.1 → NP_001342541.1 zinc finger and BTB domain-containing protein 43 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).

Source sequence(s)

AL929212, CV676247

Consensus CDS

CCDS15943.1

UniProtKB/Swiss-Prot

Q9DAI4

UniProtKB/TrEMBL

Q3UGQ6

Conserved Domains (3) summary

sd00017
Location:376 → 394

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18227
Location:8 → 128

BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)

pfam13465
Location:414 → 437

zf-H2C2_2; Zinc-finger double domain
NM_027947.2 → NP_082223.2 zinc finger and BTB domain-containing protein 43 isoform a

See identical proteins and their annotated locations for NP_082223.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AK005818, AL929212, BC043117

Consensus CDS

CCDS15942.1

UniProtKB/TrEMBL

G3X9N4, Q3UGQ6

Related

ENSMUSP00000108781.3, ENSMUST00000113156.2

Conserved Domains (3) summary

sd00017
Location:413 → 431

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:60 → 160

BTB; BTB/POZ domain

pfam13465
Location:451 → 474

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

33340299..33358592 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498349.4 → XP_006498412.1 zinc finger and BTB domain-containing protein 43 isoform X1

See identical proteins and their annotated locations for XP_006498412.1

UniProtKB/Swiss-Prot

Q9DAI4

UniProtKB/TrEMBL

Q3UGQ6

Conserved Domains (3) summary

sd00017
Location:376 → 394

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18227
Location:8 → 128

BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)

pfam13465
Location:414 → 437

zf-H2C2_2; Zinc-finger double domain