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    Zfp819 zinc finger protein 819 [ Mus musculus (house mouse) ]

    Gene ID: 74400, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp819provided by MGI
    Official Full Name
    zinc finger protein 819provided by MGI
    Primary source
    MGI:MGI:1921650
    See related
    Ensembl:ENSMUSG00000055102 AllianceGenome:MGI:1921650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930427I11Rik; 4933405K07Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of apoptotic process. Located in nucleus. Is expressed in brain; early conceptus; eye; and inner ear. Orthologous to human ZNF175 (zinc finger protein 175). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.3) and CNS E11.5 (RPKM 0.1) See more
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    Genomic context

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    See Zfp819 in Genome Data Viewer
    Location:
    7 B3; 7 28.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43256559..43267703)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43607135..43618279)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 658 Neighboring gene STARR-positive B cell enhancer ABC_E9290 Neighboring gene zinc finger protein 719 Neighboring gene STARR-seq mESC enhancer starr_18778 Neighboring gene STARR-seq mESC enhancer starr_18779 Neighboring gene CEA cell adhesion molecule 18 Neighboring gene sialic acid binding Ig-like lectin E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819. Fernandes LP, et al. Sci Adv, 2022 Oct 28. PMID 36306355, Free PMC Article
    2. Identification and characterization of reproductive KRAB-ZF genes in mice. Jin S, et al. Gene, 2015 Jul 1. PMID 25827285
    3. Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells. Tan X, et al. Stem Cell Res, 2013 Nov. PMID 23954693
    4. Generation and characterization of yeast two-hybrid cDNA libraries derived from two distinct mouse pluripotent cell types. Zheng Y, et al. Mol Biotechnol, 2013 Jun. PMID 22674187, Free PMC Article
    5. Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. Sah RK, et al. PLoS One, 2019. PMID 31291246, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819.
      Title: A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819.
    2. Results show that Zfp819 is expressed exclusively in spermatogenic cells. Its overexpression suppressed cell proliferation and induced apoptosis.
      Title: Identification and characterization of reproductive KRAB-ZF genes in mice.
    3. Zfp819 is a novel pluripotency-related factor and unveiled its function in genomic integrity maintenance mechanisms of mouse embryonic stem cells.
      Title: Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 819

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355131.1 → NP_001342060.1  zinc finger protein 819 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154108
      Consensus CDS
      CCDS90218.1
      UniProtKB/TrEMBL
      E9Q5X9
      Related
      ENSMUSP00000113867.2, ENSMUST00000120935.2
      Conserved Domains (3) summary
      COG5048
      Location:217 → 455
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:463 → 487
      zf-H2C2_2; Zinc-finger double domain

    2. NM_028913.3 → NP_083189.2  zinc finger protein 819 isoform 1

      See identical proteins and their annotated locations for NP_083189.2

      Status: VALIDATED

      Source sequence(s)
      AC154108, AK016669
      Consensus CDS
      CCDS21176.1
      UniProtKB/TrEMBL
      Q80V81
      Related
      ENSMUSP00000032661.7, ENSMUST00000032661.14
      Conserved Domains (4) summary
      smart00349
      Location:27 → 81
      KRAB; krueppel associated box
      COG5048
      Location:293 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:539 → 563
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43256559..43267703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312353.2 → XP_017167842.1  zinc finger protein 819 isoform X1

      UniProtKB/TrEMBL
      Q80V81
      Conserved Domains (4) summary
      smart00349
      Location:27 → 81
      KRAB; krueppel associated box
      COG5048
      Location:293 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:539 → 563
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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