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    Bod1l biorientation of chromosomes in cell division 1-like [ Mus musculus (house mouse) ]

    Gene ID: 665775, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bod1lprovided by MGI
    Official Full Name
    biorientation of chromosomes in cell division 1-likeprovided by MGI
    Primary source
    MGI:MGI:2444804
    See related
    Ensembl:ENSMUSG00000061755 AllianceGenome:MGI:2444804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FAM44A; mKIAA1327; A230054D04Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA damage response and replication fork processing. Predicted to be located in nucleoplasm. Predicted to be part of Set1C/COMPASS complex. Is expressed in forelimb; forelimb bud; hindlimb; hindlimb bud; and limb. Orthologous to human BOD1L1 (biorientation of chromosomes in cell division 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.0), cerebellum adult (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bod1l in Genome Data Viewer
    Location:
    5 B3; 5 22.58 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (41944881..42001695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (41787538..41844355, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) III (DNA directed) polypeptide F pseudogene Neighboring gene STARR-seq mESC enhancer starr_12949 Neighboring gene predicted gene, 46910 Neighboring gene NK3 homeobox 2 Neighboring gene STARR-positive B cell enhancer ABC_E11286 Neighboring gene tubulin polyglutamylase complex subunit 2 pseudogene Neighboring gene microRNA 6414

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Monoclonal antibodies recognize antigen expressed by osteoblasts. Benayahu D, et al. J Bone Miner Res, 1995 Oct. PMID 8686505
    2. H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ. Bayley R, et al. Mol Cell, 2022 May 19. PMID 35439434, Free PMC Article
    3. An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice. Castro JP, et al. Elife, 2019 Jun 6. PMID 31169497, Free PMC Article
    4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    5. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    biorientation of chromosomes in cell division protein 1-like 1
    Names
    family with sequence similarity 44, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081422.3 → NP_001074891.1  biorientation of chromosomes in cell division protein 1-like 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102858, AC157932
      Consensus CDS
      CCDS39079.1
      UniProtKB/Swiss-Prot
      E9Q6J5, O35243, Q3TR39, Q3USW6, Q80TF0, Q8BHG7
      Related
      ENSMUSP00000058618.8, ENSMUST00000050556.11
      Conserved Domains (2) summary
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
      pfam10310
      Location:183 → 280
      DUF2413; Protein of unknown function (DUF2413)

    2. NM_001310601.1 → NP_001297530.1  biorientation of chromosomes in cell division protein 1-like 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC102858, AC157932
      Consensus CDS
      CCDS80273.1
      UniProtKB/Swiss-Prot
      E9Q6J5
      Related
      ENSMUSP00000144359.2, ENSMUST00000202908.2
      Conserved Domains (2) summary
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
      pfam10310
      Location:183 → 280
      DUF2413; Protein of unknown function (DUF2413)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      41944881..42001695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504050.5 → XP_006504113.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    2. XM_017321065.1 → XP_017176554.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X10

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    3. XM_006504055.5 → XP_006504118.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X8

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    4. XM_017321064.1 → XP_017176553.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X9

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    5. XM_006504054.5 → XP_006504117.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X7

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    6. XM_017321063.1 → XP_017176552.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X6

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    7. XM_036165408.1 → XP_036021301.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X4

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    8. XM_017321062.1 → XP_017176551.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X5

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    9. XM_006504053.3 → XP_006504116.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X3

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    10. XM_006504051.3 → XP_006504114.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X2

      Conserved Domains (2) summary
      PTZ00121
      Location:303 → 1041
      PTZ00121; MAEBL; Provisional
      pfam05205
      Location:55 → 148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q6J5.1 GenPept UniProtKB/Swiss-Prot:E9Q6J5

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