Morc2a microrchidia 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Morc2aprovided by MGI
Official Full Name: microrchidia 2Aprovided by MGI
Primary source: MGI:MGI:1921772
See related: Ensembl:ENSMUSG00000034543 AllianceGenome:MGI:1921772
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zcwcc1; 8430403M08Rik
Summary: Enables histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Is expressed in gonad; heart; nervous system; and skeletal muscle. Used to study Charcot-Marie-Tooth disease axonal type 2Z. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 13.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.56 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (3599132..3640477)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (3649189..3690477)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase.
Title: Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase.
Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis.
Title: Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis.
We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1
Title: A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.
these results demonstrate a cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY.[Morc2]
Title: Cytosolic functions of MORC2 in lipogenesis and adipogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236507

AW742696 (e-PCR)
- UniSTS:208634

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA methylation-dependent heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA methylation-dependent heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA methylation-dependent heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATPase MORC2A

Names: MORC family CW-type zinc finger protein 2A; zinc finger CW-type coiled-coil domain protein 1; zinc finger, CW-type with coiled-coil domain 1

NP_001152760.1

EC 3.6.1.3

NP_001350131.1

EC 3.6.1.3

NP_937805.1

EC 3.6.1.3

XP_006514934.1

EC 3.6.1.3

XP_011242077.1

EC 3.6.1.3

XP_036012945.1

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159288.2 → NP_001152760.1 ATPase MORC2A isoform 1

See identical proteins and their annotated locations for NP_001152760.1

Status: VALIDATED

Source sequence(s)

AK173042, AL691413

Consensus CDS

CCDS48741.1

UniProtKB/Swiss-Prot

Q5QNQ7, Q69ZX6, Q6P547

Related

ENSMUSP00000091087.3, ENSMUST00000093389.9

Conserved Domains (3) summary

pfam07496
Location:495 → 542

zf-CW; CW-type Zinc Finger

pfam13589
Location:29 → 169

HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

cl26464
Location:624 → 741

Atrophin-1; Atrophin-1 family
NM_001363202.1 → NP_001350131.1 ATPase MORC2A isoform 1

Status: VALIDATED

Source sequence(s)

AL691413

Consensus CDS

CCDS48741.1

UniProtKB/Swiss-Prot

Q5QNQ7, Q69ZX6, Q6P547

Related

ENSMUSP00000094176.4, ENSMUST00000096441.5

Conserved Domains (3) summary

pfam07496
Location:495 → 542

zf-CW; CW-type Zinc Finger

pfam13589
Location:29 → 169

HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

cl26464
Location:624 → 741

Atrophin-1; Atrophin-1 family
NM_198162.2 → NP_937805.1 ATPase MORC2A isoform 2

See identical proteins and their annotated locations for NP_937805.1

Status: VALIDATED

Source sequence(s)

AL691413, BC059243

UniProtKB/TrEMBL

Q6PCN6

Conserved Domains (4) summary

PHA03247
Location:562 → 679

PHA03247; large tegument protein UL36; Provisional

pfam07496
Location:433 → 480

zf-CW; CW-type Zinc Finger

pfam17942
Location:177 → 389

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

cl00075
Location:1 → 73

HATPase; Histidine kinase-like ATPase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

3599132..3640477

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243775.4 → XP_011242077.1 ATPase MORC2A isoform X1

See identical proteins and their annotated locations for XP_011242077.1

Conserved Domains (4) summary

PHA03247
Location:624 → 741

PHA03247; large tegument protein UL36; Provisional

cd16931
Location:18 → 135

HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains

pfam07496
Location:495 → 542

zf-CW; CW-type Zinc Finger

pfam17942
Location:239 → 451

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
XM_006514871.4 → XP_006514934.1 ATPase MORC2A isoform X1

See identical proteins and their annotated locations for XP_006514934.1

Conserved Domains (4) summary

PHA03247
Location:624 → 741

PHA03247; large tegument protein UL36; Provisional

cd16931
Location:18 → 135

HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains

pfam07496
Location:495 → 542

zf-CW; CW-type Zinc Finger

pfam17942
Location:239 → 451

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
XM_036157052.1 → XP_036012945.1 ATPase MORC2A isoform X2

UniProtKB/TrEMBL

Q6PCN6

Conserved Domains (4) summary

PHA03247
Location:562 → 679

PHA03247; large tegument protein UL36; Provisional

pfam07496
Location:433 → 480

zf-CW; CW-type Zinc Finger

pfam17942
Location:177 → 389

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

cl00075
Location:1 → 73

HATPase; Histidine kinase-like ATPase domain