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    Zfp28 zinc finger protein 28 [ Mus musculus (house mouse) ]

    Gene ID: 22690, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp28provided by MGI
    Official Full Name
    zinc finger protein 28provided by MGI
    Primary source
    MGI:MGI:99175
    See related
    Ensembl:ENSMUSG00000062861 AllianceGenome:MGI:99175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mkr-5; Zfp-28; 2810438M17Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZFP28 (ZFP28 zinc finger protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 4.3), CNS E14 (RPKM 3.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp28 in Genome Data Viewer
    Location:
    7 A1; 7 3.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6386317..6399636)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6383206..6396637)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38944 Neighboring gene zinc finger protein 582 Neighboring gene STARR-positive B cell enhancer ABC_E8944 Neighboring gene STARR-positive B cell enhancer ABC_E442 Neighboring gene STARR-seq mESC enhancer starr_17978 Neighboring gene zinc finger protein 78 Neighboring gene STARR-positive B cell enhancer ABC_E8150 Neighboring gene predicted gene, 53349 Neighboring gene small integral membrane protein 17 Neighboring gene STARR-seq mESC enhancer starr_17979 Neighboring gene olfactory receptor family 2 subfamily BD member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence contiguity and allelic structure for the murine zinc finger-encoding gene mKr5. Udy GB. Gene, 1994 Oct 21. PMID 7958967
    2. Zinc finger protein 28 as a novel melanoma-related molecule. Yajima I, et al. J Dermatol Sci, 2009 Jul. PMID 19329283
    3. Specific and ubiquitous expression of different Zn finger protein genes in the mouse. Chowdhury K, et al. Nucleic Acids Res, 1988 Nov 11. PMID 3143103, Free PMC Article
    4. ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis. Gustafson EA, et al. Mol Cell Biol, 2020 Mar 16. PMID 31932482, Free PMC Article
    5. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 28
    Names
    protein mKR5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175247.3 → NP_780456.2  zinc finger protein 28

      See identical proteins and their annotated locations for NP_780456.2

      Status: VALIDATED

      Source sequence(s)
      AK173170, AW488938, BY011080
      Consensus CDS
      CCDS39752.1
      UniProtKB/Swiss-Prot
      P10078, Q61776, Q8BT11, Q8C836
      Related
      ENSMUSP00000079812.8, ENSMUST00000081022.9
      Conserved Domains (4) summary
      smart00349
      Location:103 → 163
      KRAB; krueppel associated box
      COG5048
      Location:341 → 763
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:243 → 281
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6386317..6399636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10078.3 GenPept UniProtKB/Swiss-Prot:P10078

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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