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    Dyrk1b dual-specificity tyrosine phosphorylation regulated kinase 1b [ Mus musculus (house mouse) ]

    Gene ID: 13549, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Dyrk1bprovided by MGI
    Official Full Name
    dual-specificity tyrosine phosphorylation regulated kinase 1bprovided by MGI
    Primary source
    MGI:MGI:1330302
    See related
    Ensembl:ENSMUSG00000002409 AllianceGenome:MGI:1330302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mirk
    Summary
    Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within myoblast fusion. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 39.4), thymus adult (RPKM 16.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dyrk1b in Genome Data Viewer
    Location:
    7 A3; 7 16.67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27878880..27896896)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28179447..28197910)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6526 Neighboring gene predicted gene, 31024 Neighboring gene fibrillarin Neighboring gene STARR-positive B cell enhancer ABC_E9687 Neighboring gene STARR-seq mESC enhancer starr_18404 Neighboring gene STARR-seq mESC enhancer starr_18406 Neighboring gene STARR-seq mESC enhancer starr_18407 Neighboring gene STARR-seq mESC enhancer starr_18408 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene leucine twenty homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer.
      Title: DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer.
    2. Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response.
      Title: Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response.
    3. DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
      Title: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
    4. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
      Title: Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
    5. we demonstrated that Anxa1, Anxa2, and Dyrk1b are upregulated at both the transcriptional and translational levels by the overexpression of GAS1
      Title: Annexin A1, Annexin A2, and Dyrk 1B are upregulated during GAS1-induced cell cycle arrest.
    6. Through the activation of DYRK1B, Hedgehog signaling facilitates microtubule-dependent processes such as intracellular mitochondrial transport, mesenchymal cell polarization or directed cell migration.
      Title: DYRK1B regulates Hedgehog-induced microtubule acetylation.
    7. results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
      Title: Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.
    8. Cirp functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b.
      Title: Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice.
    9. BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk
      Title: G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.
    10. Mirk may function together with GSK3beta to assist cell arrest by destabilizing cyclin D1.
      Title: Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adipose tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Names
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
    NP_001033046.1
    NP_001258299.1
    NP_034222.1
    XP_006539589.1
    XP_006539590.1
    XP_030097944.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037957.4 → NP_001033046.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

      See identical proteins and their annotated locations for NP_001033046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform p69, also known as isoform b.
      Source sequence(s)
      AC141883
      Consensus CDS
      CCDS21037.1
      UniProtKB/Swiss-Prot
      Q3UFR5, Q70UR5, Q9EPM2, Q9Z188
      Related
      ENSMUSP00000083064.7, ENSMUST00000085901.13
      Conserved Domains (2) summary
      smart00220
      Location:111 → 431
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:97 → 436
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    2. NM_001271370.2 → NP_001258299.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p75

      See identical proteins and their annotated locations for NP_001258299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), uses an alternate 5' structure, compared to variant 1. This difference causes translation initiation at an upstream AUG and results in an isoform (p75), also known as isoform c, that has a longer N-terminus, compared to isoform p69.
      Source sequence(s)
      AC141883
      Consensus CDS
      CCDS85251.1
      UniProtKB/Swiss-Prot
      Q9Z188
      Related
      ENSMUSP00000133431.3, ENSMUST00000172467.8
      Conserved Domains (2) summary
      smart00220
      Location:171 → 491
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:157 → 496
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    3. NM_010092.3 → NP_034222.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

      See identical proteins and their annotated locations for NP_034222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform p65, also known as isoform a, which is shorter than isoform p69.
      Source sequence(s)
      AC141883
      Consensus CDS
      CCDS57532.1
      UniProtKB/Swiss-Prot
      Q9Z188
      Related
      ENSMUSP00000133719.2, ENSMUST00000172761.8
      Conserved Domains (2) summary
      smart00220
      Location:111 → 391
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14226
      Location:97 → 396
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27878880..27896896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242084.2 → XP_030097944.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

      Conserved Domains (1) summary
      cd14226
      Location:97 → 408
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    2. XM_006539526.4 → XP_006539589.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      Conserved Domains (2) summary
      PHA03378
      Location:3 → 147
      PHA03378; EBNA-3B; Provisional
      cd14226
      Location:157 → 468
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    3. XM_006539527.5 → XP_006539590.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

      Conserved Domains (2) summary
      PHA03378
      Location:3 → 147
      PHA03378; EBNA-3B; Provisional
      cd14226
      Location:157 → 456
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RNA

    1. XR_003946384.2 RNA Sequence

    2. XR_003946385.2 RNA Sequence

    3. XR_003946383.2 RNA Sequence

    4. XR_004934006.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z188.3 GenPept UniProtKB/Swiss-Prot:Q9Z188

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