Socs7 suppressor of cytokine signaling 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Socs7provided by MGI
Official Full Name: suppressor of cytokine signaling 7provided by MGI
Primary source: MGI:MGI:2651588
See related: Ensembl:ENSMUSG00000038485 AllianceGenome:MGI:2651588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nap4; 2310063P06Rik
Summary: Enables phosphorylation-dependent protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including brain development; fat cell differentiation; and insulin receptor signaling pathway. Part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including brain; eye; liver; lung; and testis. Orthologous to human SOCS7 (suppressor of cytokine signaling 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 29.8), cerebellum adult (RPKM 12.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 60.96 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97253044..97289368)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97362292..97398542)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transforming growth factor-beta1 negatively regulates SOCS7 via EGR1 during wound healing.
Title: Transforming growth factor-β1 negatively regulates SOCS7 via EGR1 during wound healing.
miR-221 promotes keratinocyte proliferation and migration by targeting SOCS7 and is regulated by YB-1.
Title: miR-221 promotes keratinocyte proliferation and migration by targeting SOCS7 and is regulated by YB-1.
PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
Title: PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex.
Title: Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
Data implicate SOCS7 in the modulation of allergic inflammation and demonstrate that SOCS7 is involved in the regulation of TSLP signaling in mast cells.
Title: Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation.
data suggest that SOCS7 is a potent regulator of glucose homeostasis and insulin signaling
Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
prominent expression of Socs7 in the brain suggests an important functional role of SOCS7 in this organ
Title: Development of hydrocephalus in mice lacking SOCS7.
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
Title: SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127135 (e-PCR)
- UniSTS:208742

NoName (e-PCR)
- UniSTS:236716

NoName (e-PCR)
- UniSTS:236725

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphorylation-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within layer formation in cerebral cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within radial glia guided migration of Purkinje cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of cytokine signaling 7

Names: Nck, Ash and phospholipase C binding protein; SH2 domain containing SOCS box protein SOCS7; SOCS-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138657.4 → NP_619598.2 suppressor of cytokine signaling 7

Status: VALIDATED

Source sequence(s)

AK147580, AL596088

Consensus CDS

CCDS25319.2

UniProtKB/Swiss-Prot

B1AQY1, Q3UH08, Q8VHQ2

UniProtKB/TrEMBL

A0A571BEJ5

Related

ENSMUSP00000158611.2, ENSMUST00000238729.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

97253044..97289368

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532528.4 → XP_006532591.1 suppressor of cytokine signaling 7 isoform X1

UniProtKB/Swiss-Prot

B1AQY1, Q3UH08, Q8VHQ2

Conserved Domains (2) summary

cd10388
Location:422 → 522

SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03741
Location:546 → 594

SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...
XM_006532529.4 → XP_006532592.1 suppressor of cytokine signaling 7 isoform X2

UniProtKB/Swiss-Prot

B1AQY1, Q3UH08, Q8VHQ2

Conserved Domains (2) summary

cd10388
Location:387 → 487

SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03741
Location:511 → 559

SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...