BAGE B melanoma antigen [Homo sapiens (human)] - Gene

Summary

Official Symbol: BAGEprovided by HGNC
Official Full Name: B melanoma antigenprovided by HGNC
Primary source: HGNC:HGNC:942
See related: MIM:605167; AllianceGenome:HGNC:942
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAGE1; CT2.1
Summary: This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided by RefSeq, Jul 2008]
Annotation information: Annotation category: not annotated on reference assembly
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Genomic context

Location:: 21p11.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (10855966..10911366)

Chromosome 13 - NC_060937.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_060937.1 Chromosome 13 Alternate T2T-CHM13v2.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor-specific antigen BAGE may play a role in the occurrence and development of ovarian cancer and can be used as one of the important indicators for early diagnosis, efficacy evaluation and prognostic determination of ovarian cancer.
Title: Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines.
BAGE loci were hypomethylated in 81% of colorectal carcinoma samples.
Title: BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection.
five new BAGE genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 and nine BAGE gene fragments mapping to the juxtacentromeric regions of chromosomes 9, 13, 18, and 21
Title: New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482820

D11S2921 (e-PCR)
- UniSTS:152074

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

BAGE__4427 (e-PCR)
- UniSTS:463238

RH79776 (e-PCR)
- UniSTS:91314

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: B melanoma antigen 1

Names: antigen MZ2-BA; cancer/testis antigen 2.1; cancer/testis antigen family 2, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001187.1 → NP_001178.1 B melanoma antigen 1 precursor

See identical proteins and their annotated locations for NP_001178.1

Status: REVIEWED

Source sequence(s)

U19180

UniProtKB/Swiss-Prot

A4IF47, Q13072

UniProtKB/TrEMBL

Q29RY1

Conserved Domains (1) summary

pfam08180
Location:1 → 28

BAGE; B melanoma antigen family