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    OR7D2 olfactory receptor family 7 subfamily D member 2 [ Homo sapiens (human) ]

    Gene ID: 162998, updated on 28-Oct-2024

    Summary

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    Official Symbol
    OR7D2provided by HGNC
    Official Full Name
    olfactory receptor family 7 subfamily D member 2provided by HGNC
    Primary source
    HGNC:HGNC:8378
    See related
    Ensembl:ENSG00000188000 AllianceGenome:HGNC:8378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR19-4; OR19-10; HTPCRH03
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
    all
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    Genomic context

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    See OR7D2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9178979..9188818)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9305174..9315012)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9289655..9299494)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily G member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13926 Neighboring gene zinc finger protein 317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:9270512-9271012 Neighboring gene elongin C pseudogene 29 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9300121-9300643 Neighboring gene olfactory receptor family 7 subfamily E member 16 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 25 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Wilanowski T, et al. Mech Dev, 2002 Jun. PMID 12175488
    2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier M, et al. Nature, 1992 Jan 30. PMID 1370859
    3. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
    4. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
    5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38149

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 7D2
    Names
    olfactory receptor 19-4
    olfactory receptor OR19-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386112.1 → NP_001373041.1  olfactory receptor 7D2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC011464
      Consensus CDS
      CCDS32900.1
      UniProtKB/Swiss-Prot
      Q6IFJ7, Q8N133, Q96RA2
      UniProtKB/TrEMBL
      A0A126GVY4
      Related
      ENSP00000492939.1, ENST00000642043.1
      Conserved Domains (1) summary
      cd15234
      Location:25 → 301
      7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_175883.4 → NP_787079.1  olfactory receptor 7D2

      See identical proteins and their annotated locations for NP_787079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC011464
      Consensus CDS
      CCDS32900.1
      UniProtKB/Swiss-Prot
      Q6IFJ7, Q8N133, Q96RA2
      UniProtKB/TrEMBL
      A0A126GVY4
      Related
      ENSP00000493200.1, ENST00000641288.2
      Conserved Domains (1) summary
      cd15234
      Location:25 → 301
      7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9178979..9188818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438317.1 → XP_047294273.1  olfactory receptor 7D2 isoform X1

      UniProtKB/Swiss-Prot
      Q6IFJ7, Q8N133, Q96RA2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9305174..9315012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320058.1 → XP_054176033.1  olfactory receptor 7D2 isoform X1

      UniProtKB/Swiss-Prot
      Q6IFJ7, Q8N133, Q96RA2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RA2.2 GenPept UniProtKB/Swiss-Prot:Q96RA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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