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    Thbd thrombomodulin [ Mus musculus (house mouse) ]

    Gene ID: 21824, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Thbdprovided by MGI
    Official Full Name
    thrombomodulinprovided by MGI
    Primary source
    MGI:MGI:98736
    See related
    Ensembl:ENSMUSG00000074743 AllianceGenome:MGI:98736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TM; CD141
    Summary
    Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Acts upstream of or within female pregnancy. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; lung; and skeleton. Used to study thrombophilia. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human all
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    Genomic context

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    See Thbd in Genome Data Viewer
    Location:
    2 G3; 2 73.45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148246391..148250108, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148404471..148408188, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39957 Neighboring gene STARR-seq mESC enhancer starr_05968 Neighboring gene STARR-positive B cell enhancer ABC_E9205 Neighboring gene STARR-seq mESC enhancer starr_05969 Neighboring gene somatostatin receptor 4 Neighboring gene STARR-seq mESC enhancer starr_05970 Neighboring gene STARR-positive B cell enhancer ABC_E5997 Neighboring gene STARR-positive B cell enhancer ABC_E2051 Neighboring gene CD93 antigen Neighboring gene STARR-seq mESC enhancer starr_05971 Neighboring gene predicted gene, 46770 Neighboring gene STARR-seq mESC enhancer starr_05973

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intravascular coagulation activation in a murine model of thrombomodulin deficiency: effects of lesion size, age, and hypoxia on fibrin deposition. Healy AM, et al. Blood, 1998 Dec 1. PMID 9834223
    2. Thrombomodulin regulates keratinocyte differentiation and promotes wound healing. Cheng TL, et al. J Invest Dermatol, 2013 Jun. PMID 23321922
    3. The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition. Wang H, et al. Thromb Haemost, 2012 Dec. PMID 23014597
    4. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Geiger H, et al. Nat Med, 2012 Jul. PMID 22729286, Free PMC Article
    5. Maintenance and repair of the lung endothelium does not involve contributions from marrow-derived endothelial precursor cells. Ohle SJ, et al. Am J Respir Cell Mol Biol, 2012 Jul. PMID 22323363, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction following Intraportal Transplantation.
      Title: Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction following Intraportal Transplantation.
    2. Epigenetic repression of THBD transcription by BRG1 contributes to deep vein thrombosis.
      Title: Epigenetic repression of THBD transcription by BRG1 contributes to deep vein thrombosis.
    3. Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses.
      Title: Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses.
    4. Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression.
      Title: Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression.
    5. Role of thrombomodulin expression on hematopoietic stem cells.
      Title: Role of thrombomodulin expression on hematopoietic stem cells.
    6. Reduced Glomerular Endothelial Thrombomodulin Is Associated with Glomerular Macrophage Infiltration in Diabetic Nephropathy.
      Title: Reduced Glomerular Endothelial Thrombomodulin Is Associated with Glomerular Macrophage Infiltration in Diabetic Nephropathy.
    7. Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain-Brief Report.
      Title: Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain-Brief Report.
    8. In Erg deletion(iEC-KO) mice, thrombomodulin (TM) expression is decreased in liver and lung microvasculature exposed to low shear stress (SS) but not in blood vessels exposed to high SS.
      Title: The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature.
    9. Plasminogen (Plg) binds to thrombomodulin (TM) in cutaneous wound healing. TM facilitates the activation of Plg to Plm in keratinocytes. Epithelial TM regulates Plg-enhanced wound healing through VEGF expression. Our findings suggest that activation of Plg/TM signaling may hold therapeutic potential for chronic wounds in diabetic or non-diabetic individuals.
      Title: Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing.
    10. macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice
      Title: Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewis(y).
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (12)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of coagulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to X-ray IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of serine-type endopeptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of serine-type endopeptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thrombomodulin
    Names
    fetomodulin
    snoRNA MBII-339

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009378.3 → NP_033404.1  thrombomodulin precursor

      See identical proteins and their annotated locations for NP_033404.1

      Status: VALIDATED

      Source sequence(s)
      AL935149
      Consensus CDS
      CCDS16838.1
      UniProtKB/Swiss-Prot
      P15306
      UniProtKB/TrEMBL
      Q543W3, Q8BJB5
      Related
      ENSMUSP00000096877.4, ENSMUST00000099270.5
      Conserved Domains (5) summary
      pfam06247
      Location:346 → 467
      Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
      pfam07645
      Location:324 → 360
      EGF_CA; Calcium-binding EGF domain
      pfam09064
      Location:405 → 438
      Tme5_EGF_like; Thrombomodulin like fifth domain, EGF-like
      pfam14670
      Location:244 → 279
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl02432
      Location:30 → 169
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      148246391..148250108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15306.1 GenPept UniProtKB/Swiss-Prot:P15306

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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