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    Uap1l1 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 227620, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Uap1l1provided by MGI
    Official Full Name
    UDP-N-acteylglucosamine pyrophosphorylase 1-like 1provided by MGI
    Primary source
    MGI:MGI:2443318
    See related
    Ensembl:ENSMUSG00000026956 AllianceGenome:MGI:2443318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730445F03Rik
    Summary
    Predicted to enable UDP-N-acetylglucosamine diphosphorylase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Orthologous to human UAP1L1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in placenta adult (RPKM 65.1), duodenum adult (RPKM 59.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uap1l1 in Genome Data Viewer
    Location:
    2 A3; 2 17.19 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25251501..25255695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25361489..25365682, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dipeptidylpeptidase 7 Neighboring gene predicted gene, 46732 Neighboring gene STARR-positive B cell enhancer ABC_E9505 Neighboring gene suppressor APC domain containing 2 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of UAP1L1 as a critical factor for protein O-GlcNAcylation and cell proliferation in human hepatoma cells. Lai CY, et al. Oncogene, 2019 Jan. PMID 30097606
    2. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine diphosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
    NP_001028465.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033293.3 → NP_001028465.1  UDP-N-acetylhexosamine pyrophosphorylase-like protein 1

      See identical proteins and their annotated locations for NP_001028465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AK159787, AL732557, BE944661, BY096323
      Consensus CDS
      CCDS15767.1
      UniProtKB/Swiss-Prot
      A1L3D3, Q3TW96, Q6KAP8, Q6NVB6, Q80XP4
      UniProtKB/TrEMBL
      Q8BVK3
      Related
      ENSMUSP00000099989.4, ENSMUST00000102925.4
      Conserved Domains (1) summary
      cd04193
      Location:92 → 413
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

    RNA

    1. NR_149315.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK131159, BE944661, BY096323

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25251501..25255695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939546.1 RNA Sequence

    2. XR_374072.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TW96.1 GenPept UniProtKB/Swiss-Prot:Q3TW96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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