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    Tmem132e transmembrane protein 132E [ Mus musculus (house mouse) ]

    Gene ID: 270893, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tmem132eprovided by MGI
    Official Full Name
    transmembrane protein 132Eprovided by MGI
    Primary source
    MGI:MGI:2685490
    See related
    Ensembl:ENSMUSG00000020701 AllianceGenome:MGI:2685490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm644
    Summary
    Predicted to be involved in posterior lateral line neuromast hair cell development. Located in cell body. Is expressed in nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to human TMEM132E (transmembrane protein 132E). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in placenta adult (RPKM 5.4), cerebellum adult (RPKM 3.2) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem132e in Genome Data Viewer
    Location:
    11 C; 11 50.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82279281..82338447)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82388852..82447621)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 1 Neighboring gene STARR-seq mESC enhancer starr_30173 Neighboring gene predicted gene, 38577 Neighboring gene predicted gene, 53691 Neighboring gene predicted gene, 24612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heterogeneity of breakpoints in non-LCR-mediated large constitutional deletions of the 17q11.2 NF1 tumour suppressor region. Kehrer-Sawatzki H, et al. J Med Genet, 2003 Oct. PMID 14569139, Free PMC Article
    2. Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing loss DFNB99. Li J, et al. Hum Mutat, 2015 Jan. PMID 25331638
    3. Differential expression of the Tmem132 family genes in the developing mouse nervous system. Wang Y, et al. Gene Expr Patterns, 2022 Sep. PMID 35690356, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in posterior lateral line neuromast hair cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in posterior lateral line neuromast hair cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 132E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304439.2 → NP_001291368.1  transmembrane protein 132E precursor

      Status: VALIDATED

      Source sequence(s)
      AL645797
      Consensus CDS
      CCDS25144.2
      UniProtKB/Swiss-Prot
      A0A0A0MQ93, B7ZN59, Q5SUX0, Q6IEE6
      UniProtKB/TrEMBL
      A0A494B870
      Related
      ENSMUSP00000052484.5, ENSMUST00000054245.8
      Conserved Domains (3) summary
      pfam15705
      Location:45 → 175
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:877 → 942
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:451 → 796
      TMEM132; Transmembrane protein family 132

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82279281..82338447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533452.5 → XP_006533515.1  transmembrane protein 132E isoform X2

      Conserved Domains (2) summary
      pfam15705
      Location:45 → 176
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam16070
      Location:451 → 797
      TMEM132; Transmembrane protein family 132

    2. XM_036156736.1 → XP_036012629.1  transmembrane protein 132E isoform X3

      Conserved Domains (2) summary
      pfam15706
      Location:581 → 646
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:155 → 501
      TMEM132; Transmembrane protein family 132

    3. XM_006533449.5 → XP_006533512.1  transmembrane protein 132E isoform X1

      UniProtKB/TrEMBL
      A0A494B870
      Conserved Domains (3) summary
      pfam15705
      Location:47 → 178
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:879 → 944
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:453 → 799
      TMEM132; Transmembrane protein family 132

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023438.2: Suppressed sequence

      Description
      NM_023438.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IEE6.2 GenPept UniProtKB/Swiss-Prot:Q6IEE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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