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    TTC41P tetratricopeptide repeat domain 41, pseudogene [ Homo sapiens (human) ]

    Gene ID: 253724, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TTC41Pprovided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 41, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:49210
    See related
    Ensembl:ENSG00000214198 AllianceGenome:HGNC:49210
    Gene type
    pseudo
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GNN; GNNP
    Summary
    Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 1.4), thyroid (RPKM 0.5) and 20 other tissues See more
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    Genomic context

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    See TTC41P in Genome Data Viewer
    Location:
    12q23.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (103843749..103930211, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (103805522..103891911, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104237527..104323989, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene stabilin 2 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104151936-104152436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104163275-104163784 Neighboring gene 5'-nucleotidase domain containing 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23254 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23277 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:104192073-104193272 Neighboring gene uncharacterized LOC124903000 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23314 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23365 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4782 Neighboring gene uncharacterized LOC107984433 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:104252387-104253586 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104295143-104295644 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6898 Neighboring gene uncharacterized LOC124903001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6900 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23563 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104321935-104322117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6901 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23584 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23591 Neighboring gene heat shock protein 90 beta family member 1 Neighboring gene microRNA 3652 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104350309-104350822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6904 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia. van den Akker E, et al. J Virol, 2005 May. PMID 15827139, Free PMC Article
    2. Two-marker association tests yield new disease associations for coronary artery disease and hypertension. Slavin TP, et al. Hum Genet, 2011 Dec. PMID 21626137, Free PMC Article
    3. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
    4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629, Free PMC Article
    5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
    EBI GWAS Catalog

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • Grp94 neighboring nucleotidase pseudogene

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027249.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AC012386, AC012555, AC078819, AC084199
      Related
      ENST00000551270.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      103843749..103930211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      103805522..103891911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P2S7.3 GenPept UniProtKB/Swiss-Prot:Q6P2S7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials