Krt7 keratin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt7provided by MGI
Official Full Name: keratin 7provided by MGI
Primary source: MGI:MGI:96704
See related: Ensembl:ENSMUSG00000023039 AllianceGenome:MGI:96704
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K7; Krt2-7; D15Wsu77e
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be active in keratin filament. Is expressed in several structures, including alimentary system; genitourinary system; sensory organ; skin; and trophectoderm. Orthologous to human KRT7 (keratin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 403.9), placenta adult (RPKM 196.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1- F2; 15 56.88 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101310284..101325687)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101412403..101427806)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE.
Title: Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE.
Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes.
Title: Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes.
Keratin-7 deficiency resulted in increased proliferation of the bladder urothelium, although this was not associated with hyperplasia.
Title: Generation and characterisation of keratin 7 (K7) knockout mice.
The -0.25 kb region of keratin 7 promoter showed pancreatic selectivity, high activity in pancreatic cancers, & sustained transgene expression in xenografts. krt7 promoter is useful to target pancreatic ductal adenocarcinoma cells in vitro and in vivo.
Title: Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Wsu77e (e-PCR), detects polymorphism
- UniSTS:142032

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 7

Names: CK-7; Cytokeratin 7; cytokeratin-7; keratin complex 2, basic, gene 7; sarcolectin; type-II keratin Kb7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033073.3 → NP_149064.1 keratin, type II cytoskeletal 7

See identical proteins and their annotated locations for NP_149064.1

Status: VALIDATED

Source sequence(s)

AC157583, AK146914, BU755120

Consensus CDS

CCDS27851.1

UniProtKB/Swiss-Prot

Q9DCV7

Related

ENSMUSP00000069900.9, ENSMUST00000068904.9

Conserved Domains (5) summary

pfam00038
Location:84 → 396

Filament; Intermediate filament protein

pfam16208
Location:5 → 81

Keratin_2_head; Keratin type II head

cd16269
Location:189 → 200

GBP_C; coiled coil [structural motif]

cl20817
Location:104 → 220

GBP_C; Guanylate-binding protein, C-terminal domain

cl23720
Location:296 → 365

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)