CD300C CD300c molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD300Cprovided by HGNC
Official Full Name: CD300c moleculeprovided by HGNC
Primary source: HGNC:HGNC:19320
See related: Ensembl:ENSG00000167850 MIM:606786; AllianceGenome:HGNC:19320
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1
Summary: The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]
Expression: Broad expression in lung (RPKM 2.9), appendix (RPKM 2.6) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (74534635..74546115, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (75425156..75436636, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (72537212..72542254, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD300c could be considered a biomarker and therapeutic target in patients with IgE-mediated allergic diseases
Title: CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy.
Administration of CD300c-Fc protein attenuates graft-vs.-host disease (GVHD) in mice.
Title: A CD300c-Fc Fusion Protein Inhibits T Cell Immunity.
Results show that CD300c is exclusively expressed on CD56bright natural killer cells and differentially binds to phosphatidylethanolamine and phosphatidylserine. This expression is under the regulation of STAT5 and Il-4.
Title: CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
potential role in inflammatory responses
Title: CD300c is an activating receptor expressed on human monocytes.
engagement of CD300C led to Fc receptor gamma-dependent activation of mast cells and monocytes
Title: Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.
differential expression on human TH1 and TH17 cell memory subsets
Title: Differential expression of CD300a/c on human TH1 and TH17 cells.
CD300a and CD300c receptors are indistinguishable on the surface of natural killer (NK) cells. The tyrosine residue in the third ITIM motif, Tyr-267-Ala, is the most important residue for execution of the inhibitory signal.
Title: Expression and function of CD300 in NK cells.
CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs; CD300a/c RNA and surface expression were downregulated after stimulation of pDCs with TLR7 and TLR9 ligands
Title: CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands.
CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35A induces cellular activation and effector function [review]
Title: CMRF-35A, CMRF-35H: potential new CD.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular defense response	TAS Traceable Author Statement more info	PubMed
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CMRF35-like molecule 6

Names: CD300 antigen-like family member C; CD300c antigen; CMRF35 antigen; CMRF35 leukocyte immunoglobulin-like receptor; CMRF35A leukocyte immunoglobulin-like receptor; immunoglobulin superfamily member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006678.5 → NP_006669.1 CMRF35-like molecule 6 precursor

See identical proteins and their annotated locations for NP_006669.1

Status: VALIDATED

Source sequence(s)

AC079325, BC022279, BF508242

Consensus CDS

CCDS11701.1

UniProtKB/Swiss-Prot

Q08708

Related

ENSP00000329507.1, ENST00000330793.2

Conserved Domains (2) summary

cd05716
Location:30 → 119

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

cl11960
Location:95 → 183

Ig; Immunoglobulin domain