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    Ddx19b DEAD box helicase 19b [ Mus musculus (house mouse) ]

    Gene ID: 234733, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ddx19bprovided by MGI
    Official Full Name
    DEAD box helicase 19bprovided by MGI
    Primary source
    MGI:MGI:2148251
    See related
    Ensembl:ENSMUSG00000033658 AllianceGenome:MGI:2148251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810457M08Rik; 4921519L13Rik
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in nuclear envelope. Predicted to be active in cytoplasmic stress granule and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; orbito-sphenoid; and turbinate bone primordium. Orthologous to human DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 17.0), CNS E11.5 (RPKM 7.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx19b in Genome Data Viewer
    Location:
    8 E1; 8 57.88 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111729818..111758383, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111003186..111031751, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 39251 Neighboring gene STARR-positive B cell enhancer ABC_E1770 Neighboring gene DEAD box helicase 19a Neighboring gene STARR-seq mESC enhancer starr_22687 Neighboring gene predicted gene, 51551 Neighboring gene microRNA 3473d Neighboring gene STARR-positive B cell enhancer ABC_E566 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene exosome component 6 Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation. Zhang K, et al. Cell Rep, 2019 Jan 29. PMID 30699353
    2. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX19B
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b
    NP_001177715.1
    NP_001177729.1
    NP_758488.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190786.1 → NP_001177715.1  ATP-dependent RNA helicase DDX19B isoform 1

      See identical proteins and their annotated locations for NP_001177715.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK033235, AK147499, BC079644
      Consensus CDS
      CCDS57645.1
      UniProtKB/TrEMBL
      Q8BZY3
      Related
      ENSMUSP00000066806.6, ENSMUST00000065784.6
      Conserved Domains (3) summary
      PTZ00424
      Location:106 → 484
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:322 → 457
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:109 → 311
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001190800.1 → NP_001177729.1  ATP-dependent RNA helicase DDX19B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AC093451, AK013362, AK147499, BC079644
      UniProtKB/TrEMBL
      Q8R3C7
      Conserved Domains (3) summary
      smart00487
      Location:107 → 310
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:307 → 442
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:94 → 296
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_172284.5 → NP_758488.1  ATP-dependent RNA helicase DDX19B isoform 2

      See identical proteins and their annotated locations for NP_758488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093451, AK147499, BC079644
      Consensus CDS
      CCDS22669.1
      UniProtKB/TrEMBL
      Q8R3C7
      Related
      ENSMUSP00000038551.9, ENSMUST00000040241.15
      Conserved Domains (3) summary
      PTZ00424
      Location:91 → 469
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:307 → 442
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:94 → 296
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111729818..111758383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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