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    TRAP1 TNF receptor associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 10131, updated on 14-Nov-2024

    Summary

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    Official Symbol
    TRAP1provided by HGNC
    Official Full Name
    TNF receptor associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16264
    See related
    Ensembl:ENSG00000126602 MIM:606219; AllianceGenome:HGNC:16264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP75; HSP 75; HSP90L; TRAP-1
    Summary
    This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRAP1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3658037..3717524, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3685304..3744794, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3708038..3767525, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3630649-3631444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3639498-3640244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10330 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3690553-3691412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3691413-3692270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3692271-3693129 Neighboring gene deoxyribonuclease 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3694284-3695037 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3695038-3695790 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3695791-3696544 Neighboring gene uncharacterized LOC124903631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3704869-3705396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3705397-3705924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3721637-3722136 Neighboring gene uncharacterized LOC124903630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3746221-3746721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3763763-3764271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7139 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3781718-3781878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3786759-3787446 Neighboring gene CREB binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3872073-3872574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3872575-3873074 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3909888-3910072 Neighboring gene DPPA3 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 6998 Neighboring gene Sharpr-MPRA regulatory region 1734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7142 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3930393-3930969 Neighboring gene long intergenic non-protein coding RNA 2861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells. Guzzo G, et al. Oncotarget, 2014 Dec 15. PMID 25564869, Free PMC Article
    2. TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma. Lettini G, et al. Cell Death Differ, 2016 Nov 1. PMID 27662365, Free PMC Article
    3. 2.4 Å resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix. Sung N, et al. Acta Crystallogr D Struct Biol, 2016 Aug. PMID 27487821, Free PMC Article
    4. TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells. Palladino G, et al. Endocr Relat Cancer, 2016 Sep. PMID 27422900
    5. Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate. Sung N, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929380, Free PMC Article

    See all (252) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
      Title: TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
    2. TRAP1 modulates mitochondrial biogenesis via PGC-1alpha/TFAM signalling pathway in colorectal cancer cells.
      Title: TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells.
    3. Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
      Title: Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
    4. Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins.
      Title: Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins.
    5. Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.
      Title: Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.
    6. The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
      Title: The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
    7. Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer.
      Title: Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer.
    8. TRAP1 Chaperones the Metabolic Switch in Cancer.
      Title: TRAP1 Chaperones the Metabolic Switch in Cancer.
    9. TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation.
      Title: TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation.
    10. HIF1alpha-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
      Title: HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of TNF receptor-associated protein 1 (TRAP1; HSP90L; HSP75) in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational attenuation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 75 kDa, mitochondrial
    Names
    TNFR-associated protein 1
    heat shock protein family C member 5
    testicular tissue protein Li 209
    tumor necrosis factor type 1 receptor-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033088.1 RefSeqGene

      Range
      5074..64561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272049.2 → NP_001258978.1  heat shock protein 75 kDa, mitochondrial isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC006111, AK223205, AK299127, DB452880
      Consensus CDS
      CCDS61824.1
      UniProtKB/TrEMBL
      Q53FS6
      Related
      ENSP00000442070.1, ENST00000538171.5
      Conserved Domains (3) summary
      PRK05218
      Location:34 → 649
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:210 → 648
      HSP90; Hsp90 protein
      pfam02518
      Location:60 → 205
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    2. NM_016292.3 → NP_057376.2  heat shock protein 75 kDa, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_057376.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF154108, BC018950, DB452880
      Consensus CDS
      CCDS10508.1
      UniProtKB/Swiss-Prot
      B4DR68, D3DUC8, F5H897, O43642, O75235, Q12931, Q9UHL5
      UniProtKB/TrEMBL
      A0A140VJY2, Q53FS6
      Related
      ENSP00000246957.5, ENST00000246957.10
      Conserved Domains (1) summary
      PRK05218
      Location:87 → 702
      PRK05218; heat shock protein 90; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3658037..3717524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522345.3 → XP_011520647.1  heat shock protein 75 kDa, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011520647.1

      UniProtKB/TrEMBL
      I3L0K7
      Related
      ENSP00000458166.1, ENST00000575671.5
      Conserved Domains (3) summary
      PRK05218
      Location:2 → 562
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:123 → 561
      HSP90; Hsp90 protein
      pfam02518
      Location:2 → 118
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3685304..3744794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379372.1 → XP_054235347.1  heat shock protein 75 kDa, mitochondrial isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12931.3 GenPept UniProtKB/Swiss-Prot:Q12931

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools