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    Abca6 ATP-binding cassette, sub-family A member 6 [ Mus musculus (house mouse) ]

    Gene ID: 76184, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Abca6provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family A member 6provided by MGI
    Primary source
    MGI:MGI:1923434
    See related
    Ensembl:ENSMUSG00000044749 AllianceGenome:MGI:1923434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330565N06Rik
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in Golgi membrane; nucleoplasm; and plasma membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in tail. Orthologous to human ABCA6 (ATP binding cassette subfamily A member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 8.7), liver E18 (RPKM 8.5) and 9 other tissues See more
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    Genomic context

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    See Abca6 in Genome Data Viewer
    Location:
    11 E1; 11 73.37 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (110065464..110142811, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (110174638..110251776, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A member 8a Neighboring gene ATP-binding cassette, sub-family A member 9 Neighboring gene STARR-seq mESC enhancer starr_31035 Neighboring gene STARR-positive B cell enhancer ABC_E10728 Neighboring gene STARR-positive B cell enhancer mm9_chr11:110133108-110133408 Neighboring gene STARR-seq mESC enhancer starr_31036 Neighboring gene ATP-binding cassette, sub-family A member 5 Neighboring gene predicted gene, 39445

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hypercholesterolemia risk associated Abca6 does not regulate lipoprotein metabolism in mice or hamster. He B, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Nov. PMID 34274505
    2. Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes. Annilo T, et al. Mamm Genome, 2003 Jan. PMID 12532264
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family A member 6
    Names
    ATP-binding cassette transporter sub-family A member 6
    ATP-binding cassette, sub-family A (ABC1), member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166556.1 → NP_001160028.1  ATP-binding cassette sub-family A member 6 isoform 2

      See identical proteins and their annotated locations for NP_001160028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to variant 1.
      Source sequence(s)
      AK040652, AK053384
      UniProtKB/Swiss-Prot
      Q8K441
      Related
      ENSMUST00000150988.2
      Conserved Domains (1) summary
      pfam12698
      Location:31 → 376
      ABC2_membrane_3; ABC-2 family transporter protein

    2. NM_001166557.1 → NP_001160029.1  ATP-binding cassette sub-family A member 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to variant 1.
      Source sequence(s)
      AK040652, AL603792
      UniProtKB/Swiss-Prot
      Q8K441
      Conserved Domains (1) summary
      pfam12698
      Location:31 → 314
      ABC2_membrane_3; ABC-2 family transporter protein

    3. NM_147218.2 → NP_671751.2  ATP-binding cassette sub-family A member 6 isoform 1

      See identical proteins and their annotated locations for NP_671751.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK040652, AL603792, BC132419
      Consensus CDS
      CCDS25590.1
      UniProtKB/Swiss-Prot
      A2A6R3, Q8BGH0, Q8BPT1, Q8K441
      Related
      ENSMUSP00000035458.8, ENSMUST00000044003.14
      Conserved Domains (1) summary
      TIGR01257
      Location:169 → 1600
      rim_protein; retinal-specific rim ABC transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      110065464..110142811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534413.3 → XP_006534476.1  ATP-binding cassette sub-family A member 6 isoform X1

      See identical proteins and their annotated locations for XP_006534476.1

      UniProtKB/Swiss-Prot
      A2A6R3, Q8BGH0, Q8BPT1, Q8K441
      Conserved Domains (1) summary
      TIGR01257
      Location:169 → 1600
      rim_protein; retinal-specific rim ABC transporter

    2. XM_006534414.2 → XP_006534477.1  ATP-binding cassette sub-family A member 6 isoform X1

      See identical proteins and their annotated locations for XP_006534477.1

      UniProtKB/Swiss-Prot
      A2A6R3, Q8BGH0, Q8BPT1, Q8K441
      Conserved Domains (1) summary
      TIGR01257
      Location:169 → 1600
      rim_protein; retinal-specific rim ABC transporter

    3. XM_036157058.1 → XP_036012951.1  ATP-binding cassette sub-family A member 6 isoform X2

      Conserved Domains (1) summary
      TIGR01257
      Location:169 → 1499
      rim_protein; retinal-specific rim ABC transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K441.2 GenPept UniProtKB/Swiss-Prot:Q8K441

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