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    Muc5b mucin 5, subtype B, tracheobronchial [ Mus musculus (house mouse) ]

    Gene ID: 74180, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Muc5bprovided by MGI
    Official Full Name
    mucin 5, subtype B, tracheobronchialprovided by MGI
    Primary source
    MGI:MGI:1921430
    See related
    Ensembl:ENSMUSG00000066108 AllianceGenome:MGI:1921430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MUC5; MUC9; mucin 5b; A130042M24; 2300002I04Rik
    Summary
    Acts upstream of or within defense response to bacterium and regulation of macrophage activation. Located in extracellular space. Is expressed in auditory bulla; epithelium; and respiratory system. Human ortholog(s) of this gene implicated in bronchiolitis; idiopathic pulmonary fibrosis; interstitial lung disease 2; and urinary bladder cancer. Orthologous to human MUC5B (mucin 5B, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 37.9) and lung adult (RPKM 11.8) See more
    Orthologs
    human all
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    Genomic context

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    See Muc5b in Genome Data Viewer
    Location:
    7 F5; 7 87.29 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141392796..141426826)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141839059..141873089)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mucin 2 Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric Neighboring gene STARR-seq mESC enhancer starr_20496 Neighboring gene toll interacting protein Neighboring gene STARR-seq mESC enhancer starr_20497 Neighboring gene predicted gene, 32539

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/6 mice. Yu Q, et al. Exp Lung Res, 2020 Sep. PMID 32372722
    2. Cigarette smoke activates NF kappa B and induces Muc5b expression in mouse middle ear cells. Preciado D, et al. Laryngoscope, 2008 Mar. PMID 18091336, Free PMC Article
    3. Transgenic Mouse Reporter to Study Muc5b In Vivo. Desseyn JL, et al. Ann Am Thorac Soc, 2018 Nov. PMID 30431351
    4. Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments. Portal C, et al. PLoS One, 2017. PMID 28355261, Free PMC Article
    5. In vivo imaging of the Muc5b gel-forming mucin. Portal C, et al. Sci Rep, 2017 Mar 15. PMID 28294161, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis.
      Title: Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis.
    2. De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
      Title: De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
    3. Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
      Title: Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
    4. Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by Saccharopolyspora rectivirgula.
      Title: Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by Saccharopolyspora rectivirgula.
    5. Role of MUC5B during Group B Streptococcal Vaginal Colonization.
      Title: Role of MUC5B during Group B Streptococcal Vaginal Colonization.
    6. MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model.
      Title: MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model.
    7. Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
      Title: Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
    8. Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis.
      Title: Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis.
    9. Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/6 mice.
      Title: Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/6 mice.
    10. Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.
      Title: Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mucin-5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028801.2 → NP_083077.2  mucin-5B precursor

      Status: VALIDATED

      Source sequence(s)
      AK009011, AK037730, AL772165
      Consensus CDS
      CCDS52448.1
      UniProtKB/TrEMBL
      E9Q5I3, Q8K1G6
      Related
      ENSMUSP00000128276.2, ENSMUST00000165147.3
      Conserved Domains (11) summary
      PHA03255
      Location:3475 → 3621
      PHA03255; BDLF3; Provisional
      smart00041
      Location:4708 → 4790
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:4570 → 4631
      VWC; von Willebrand factor (vWF) type C domain
      smart00215
      Location:391 → 436
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:888 → 1047
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:619 → 700
      C8; This domain contains 8 conserved cysteine residues
      pfam01826
      Location:333 → 389
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam04880
      Location:1676 → 1796
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam05109
      Location:2920 → 3410
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam08742
      Location:1087 → 1157
      C8; C8 domain
      pfam13330
      Location:1574 → 1663
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141392796..141426826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508653.4 → XP_006508716.2  mucin-5B isoform X1

      UniProtKB/TrEMBL
      Q8K1G6
      Conserved Domains (11) summary
      PHA03255
      Location:3451 → 3597
      PHA03255; BDLF3; Provisional
      smart00041
      Location:4684 → 4766
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:4546 → 4607
      VWC; von Willebrand factor (vWF) type C domain
      smart00215
      Location:367 → 412
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:864 → 1023
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:595 → 676
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:2258 → 2471
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01826
      Location:309 → 365
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:4313 → 4374
      C8; C8 domain
      pfam13330
      Location:2475 → 2563
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      pfam17823
      Location:1656 → 1842
      DUF5585; Family of unknown function (DUF5585)
    Nucleotide Protein Strain
    Heading Accession and Version

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