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    Cdk19 cyclin dependent kinase 19 [ Mus musculus (house mouse) ]

    Gene ID: 78334, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdk19provided by MGI
    Official Full Name
    cyclin dependent kinase 19provided by MGI
    Primary source
    MGI:MGI:1925584
    See related
    Ensembl:ENSMUSG00000038481 AllianceGenome:MGI:1925584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDK11; Cdc2l6; mKIAA1028; 2700084L06Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; endolymphatic appendage; and otocyst. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to human CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 11.6), cortex adult (RPKM 9.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdk19 in Genome Data Viewer
    Location:
    10 B1; 10 21.94 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40225283..40359814)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40349287..40483818)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2319 Neighboring gene S-adenosylmethionine decarboxylase 1 Neighboring gene STARR-seq mESC enhancer starr_26414 Neighboring gene STARR-positive B cell enhancer ABC_E136 Neighboring gene STARR-positive B cell enhancer ABC_E5126 Neighboring gene STARR-positive B cell enhancer ABC_E6831 Neighboring gene predicted gene 8948 Neighboring gene STARR-seq mESC enhancer starr_26416 Neighboring gene STARR-seq mESC enhancer starr_26417 Neighboring gene STARR-seq mESC enhancer starr_26418 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6832 Neighboring gene predicted gene, 32234 Neighboring gene STARR-positive B cell enhancer ABC_E6833 Neighboring gene STARR-seq mESC enhancer starr_26425 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:40235225-40235444 Neighboring gene STARR-positive B cell enhancer ABC_E10601 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:40247394-40247503 Neighboring gene STARR-seq mESC enhancer starr_26426 Neighboring gene STARR-seq mESC enhancer starr_26427 Neighboring gene small nuclear ribonucleoprotein B pseudogene Neighboring gene predicted gene, 17795

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21. Zhang Z, et al. Leukemia, 2022 Apr. PMID 35110726
    2. CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF. Dannappel MV, et al. J Clin Invest, 2022 Oct 17. PMID 36006697, Free PMC Article
    3. Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Postlmayr A, et al. Development, 2020 Jun 11. PMID 32439758, Free PMC Article
    4. CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium. Prieto S, et al. EMBO Rep, 2023 Feb 6. PMID 36545778, Free PMC Article
    5. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
      Title: CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 19
    Names
    CDC2-related protein kinase 6
    cell division cycle 2-like 6 (CDK8-like)
    cell division cycle 2-like protein kinase 6
    cell division protein kinase 19
    cyclin-dependent kinase (CDC2-like) 11
    cyclin-dependent kinase 11
    NP_001161776.1
    NP_001278745.1
    NP_001278746.1
    NP_937807.2
    XP_017169653.1
    XP_030101250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168304.1 → NP_001161776.1  cyclin-dependent kinase 19 isoform 1

      See identical proteins and their annotated locations for NP_001161776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC142273, AC157652, AK053651, BC080280
      Consensus CDS
      CCDS48545.1
      UniProtKB/Swiss-Prot
      Q80TM1, Q8BWD8
      UniProtKB/TrEMBL
      B7ZMT1, Q8BKC7
      Related
      ENSMUSP00000040936.5, ENSMUST00000044672.11
      Conserved Domains (2) summary
      smart00220
      Location:22 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07867
      Location:18 → 335
      STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6

    2. NM_001291816.1 → NP_001278745.1  cyclin-dependent kinase 19 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC142273, AK147340, BC080280
      Conserved Domains (1) summary
      cl21453
      Location:1 → 215
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001291817.1 → NP_001278746.1  cyclin-dependent kinase 19 isoform 4

      See identical proteins and their annotated locations for NP_001278746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC142273, AK147340, BC062100, BC080280
      Conserved Domains (1) summary
      cl21453
      Location:1 → 162
      PKc_like; Protein Kinases, catalytic domain

    4. NM_198164.3 → NP_937807.2  cyclin-dependent kinase 19 isoform 2

      See identical proteins and their annotated locations for NP_937807.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a short protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC142273, AK053651, AK147340, BC080280
      Consensus CDS
      CCDS23795.1
      UniProtKB/TrEMBL
      G5E8L1, Q8BKC7
      Related
      ENSMUSP00000093414.3, ENSMUST00000095743.4
      Conserved Domains (2) summary
      smart00220
      Location:22 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:18 → 291
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      40225283..40359814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245390.1 → XP_030101250.1  cyclin-dependent kinase 19 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 162
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017314164.3 → XP_017169653.1  cyclin-dependent kinase 19 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 215
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWD8.1 GenPept UniProtKB/Swiss-Prot:Q8BWD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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