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    Zfp623 zinc finger protein 623 [ Mus musculus (house mouse) ]

    Gene ID: 78834, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp623provided by MGI
    Official Full Name
    zinc finger protein 623provided by MGI
    Primary source
    MGI:MGI:1926084
    See related
    Ensembl:ENSMUSG00000050846 AllianceGenome:MGI:1926084
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610029D06Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina nuclear layer. Orthologous to human ZNF623 (zinc finger protein 623). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 6.8), whole brain E14.5 (RPKM 6.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp623 in Genome Data Viewer
    Location:
    15 D3; 15 35.12 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75812798..75821251)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75940949..75949402)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene GDP-L-fucose synthase Neighboring gene STARR-seq mESC enhancer starr_39034 Neighboring gene predicted gene, 53898 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101961

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 623
    Names
    zinc finger CCCH type domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030199.3 → NP_084475.1  zinc finger protein 623

      See identical proteins and their annotated locations for NP_084475.1

      Status: PROVISIONAL

      Source sequence(s)
      AK046806
      Consensus CDS
      CCDS27556.1
      UniProtKB/TrEMBL
      Q9CY99
      Related
      ENSMUSP00000036049.7, ENSMUST00000037260.8
      Conserved Domains (5) summary
      COG5048
      Location:173 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:93 → 113
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:315 → 337
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:385 → 410
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75812798..75821251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521543.2 → XP_006521606.1  zinc finger protein 623 isoform X1

      See identical proteins and their annotated locations for XP_006521606.1

      UniProtKB/TrEMBL
      Q9CY99
      Conserved Domains (5) summary
      COG5048
      Location:173 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:93 → 113
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:315 → 337
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:385 → 410
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030248823.2 → XP_030104683.1  zinc finger protein 623 isoform X1

      UniProtKB/TrEMBL
      Q9CY99
      Conserved Domains (5) summary
      COG5048
      Location:173 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:93 → 113
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:315 → 337
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:385 → 410
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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