Bsph2 binder of sperm protein homolog 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bsph2provided by MGI
Official Full Name: binder of sperm protein homolog 2provided by MGI
Primary source: MGI:MGI:1924934
See related: Ensembl:ENSMUSG00000078800 AllianceGenome:MGI:1924934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bsph2a; 9230107M04Rik
Summary: Enables heparin binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 28.2) See more
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Genomic context

Location:: 7 A1; 7 7.93 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (13288791..13304992, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (13554866..13571067, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.
Title: Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.
These results show the existence of redundant function for murine BSPH2 and the lack of BSPH2 itself does not lead to sterility.
Title: CRISPR-Cas9-mediated mutation revealed BSPH2 protein is dispensable for male fertility.
This study could lead to a better understanding of the role of BSP proteins in sperm functions and the existence of redundant BSP proteins in the reproductive tract.
Title: Murine Binder of SPerm homolog 2 (BSPH2): the black sheep of the BSP superfamily.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: binder of sperm protein homolog 2

Names: bovine seminal plasma protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080942.2 → NP_001074411.1 binder of sperm protein homolog 2 precursor

See identical proteins and their annotated locations for NP_001074411.1

Status: PROVISIONAL

Source sequence(s)

DQ664198

Consensus CDS

CCDS52028.1

UniProtKB/Swiss-Prot

Q0Q236

Related

ENSMUSP00000104166.3, ENSMUST00000108526.6

Conserved Domains (2) summary

pfam00040
Location:85 → 126

fn2; Fibronectin type II domain

cl09951
Location:40 → 77

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...