NCOA1 nuclear receptor coactivator 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NCOA1provided by HGNC
Official Full Name: nuclear receptor coactivator 1provided by HGNC
Primary source: HGNC:HGNC:7668
See related: Ensembl:ENSG00000084676 MIM:602691; AllianceGenome:HGNC:7668
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74
Summary: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 17.5), testis (RPKM 14.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.3

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (24491254..24770702)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (24525913..24805480)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (24714123..24993571)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP-9.
Title: Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP-9.
Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma.
Title: Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma.
Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities.
Title: Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities.
Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling.
Title: Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling.
PRRX1-NCOA1-rearranged fibroblastic tumour: a clinicopathological, immunohistochemical and molecular genetic study of six cases of a potentially under-recognised, distinctive mesenchymal tumour.
Title: PRRX1-NCOA1-rearranged fibroblastic tumour: a clinicopathological, immunohistochemical and molecular genetic study of six cases of a potentially under-recognised, distinctive mesenchymal tumour.
Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
Title: Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts.
Title: Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts.
A mutant form of ERalpha associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.
Title: A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.
Steroid receptor coactivator-1 enhances the stemness of glioblastoma by activating long noncoding RNA XIST/miR-152/KLF4 pathway.
Title: Steroid receptor coactivator-1 enhances the stemness of glioblastoma by activating long noncoding RNA XIST/miR-152/KLF4 pathway.
SRF-FOXO1 and SRF-NCOA1 gene fusion occurs in a subset of well differentiated rhabdomyosarcoma of the neck muscles.
Title: SRF-FOXO1 and SRF-NCOA1 Fusion Genes Delineate a Distinctive Subset of Well-differentiated Rhabdomyosarcoma.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex	PubMed
	tat	HIV-1 Tat-induced calcium mobilization and TNF-alpha production in primary human monocytes are entirely regulated by DHP receptors	PubMed
	tat	SRC1a binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation	PubMed
Vpr	vpr	HIV-1 Vpr synergistically enhances SRC-1 ligand activated glucocorticoid receptor activity, however Vpr does not bind to SRC-1	PubMed
matrix	gag	HIV-1 MA upregulates NCOA1 gene expression in HepG2 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N23300 (e-PCR)
- UniSTS:72706

PMC170950P2 (e-PCR)
- UniSTS:271620

G09672 (e-PCR)
- UniSTS:13601

RH101961 (e-PCR)
- UniSTS:96296

D2S2124 (e-PCR)
- UniSTS:154155

WI-20578 (e-PCR)
- UniSTS:3127

A007I26 (e-PCR)
- UniSTS:5432

RH80592 (e-PCR)
- UniSTS:84302

D2S2912 (e-PCR)
- UniSTS:11358

D2S2066 (e-PCR)
- UniSTS:80763

RH45844 (e-PCR)
- UniSTS:83346

RH91145 (e-PCR)
- UniSTS:92843

WI-11298 (e-PCR)
- UniSTS:32946

STS-AA007451 (e-PCR)
- UniSTS:53458

D2S1969 (e-PCR)
- UniSTS:33007

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoid X receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to Thyroglobulin triiodothyronine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in estrogen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in hypothalamus development	IEA Inferred from Electronic Annotation more info
involved_in labyrinthine layer morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in male mating behavior	IEA Inferred from Electronic Annotation more info
involved_in peroxisome proliferator activated receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adipose tissue development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of female receptivity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by galactose	IDA Inferred from Direct Assay more info	PubMed
involved_in progesterone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to insulin stimulus	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of thyroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to progesterone	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: nuclear receptor coactivator 1

Names: Hin-2 protein; class E basic helix-loop-helix protein 74; renal carcinoma antigen NY-REN-52; steroid receptor coactivator-1

NP_001349879.1

EC 2.3.1.48

NP_001349881.1

EC 2.3.1.48

NP_001349883.1

EC 2.3.1.48

NP_001349884.1

EC 2.3.1.48

NP_003734.3

EC 2.3.1.48

NP_671756.1

EC 2.3.1.48

NP_671766.1

EC 2.3.1.48

XP_047302107.1

EC 2.3.1.48

XP_047302108.1

EC 2.3.1.48

XP_047302109.1

EC 2.3.1.48

XP_047302110.1

EC 2.3.1.48

XP_047302111.1

EC 2.3.1.48

XP_047302112.1

EC 2.3.1.48

XP_047302113.1

EC 2.3.1.48

XP_047302114.1

EC 2.3.1.48

XP_054200298.1

EC 2.3.1.48

XP_054200299.1

EC 2.3.1.48

XP_054200300.1

EC 2.3.1.48

XP_054200301.1

EC 2.3.1.48

XP_054200302.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029014.2 RefSeqGene

Range

4205..283653

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001362950.1 → NP_001349879.1 nuclear receptor coactivator 1 isoform 2

Status: REVIEWED

Source sequence(s)

AC013459, AC093798

Consensus CDS

CCDS1713.1

UniProtKB/TrEMBL

A8K1V4

Conserved Domains (9) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07469
Location:1149 → 1205

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:924 → 970

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:632 → 708

SRC-1; Steroid receptor coactivator

pfam09606
Location:974 → 1309

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:741 → 818

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:468 → 590

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
NM_001362952.1 → NP_001349881.1 nuclear receptor coactivator 1 isoform 2

Status: REVIEWED

Source sequence(s)

AC013459, AC093798

Consensus CDS

CCDS1713.1

UniProtKB/TrEMBL

A8K1V4

Related

ENSP00000385097.1, ENST00000405141.5

Conserved Domains (9) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07469
Location:1149 → 1205

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:924 → 970

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:632 → 708

SRC-1; Steroid receptor coactivator

pfam09606
Location:974 → 1309

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:741 → 818

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:468 → 590

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
NM_001362954.1 → NP_001349883.1 nuclear receptor coactivator 1 isoform 2

Status: REVIEWED

Source sequence(s)

AC013459, AC093798

Consensus CDS

CCDS1713.1

UniProtKB/TrEMBL

A8K1V4

Related

ENSP00000385195.1, ENST00000407230.5

Conserved Domains (9) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07469
Location:1149 → 1205

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:924 → 970

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:632 → 708

SRC-1; Steroid receptor coactivator

pfam09606
Location:974 → 1309

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:741 → 818

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:468 → 590

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
NM_001362955.1 → NP_001349884.1 nuclear receptor coactivator 1 isoform 2

Status: REVIEWED

Source sequence(s)

AC013459, AC093798

Consensus CDS

CCDS1713.1

UniProtKB/TrEMBL

A8K1V4

Conserved Domains (9) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07469
Location:1149 → 1205

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:924 → 970

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:632 → 708

SRC-1; Steroid receptor coactivator

pfam09606
Location:974 → 1309

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:741 → 818

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:468 → 590

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
NM_003743.5 → NP_003734.3 nuclear receptor coactivator 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as SRC1a, encodes the longest isoform (1).

Source sequence(s)

AC013459, AC093798

Consensus CDS

CCDS1712.1

UniProtKB/Swiss-Prot

O00150, O43792, O43793, Q13071, Q13420, Q15788, Q2T9G5, Q53SX3, Q6GVI5, Q7KYV3

UniProtKB/TrEMBL

A8K1V4

Related

ENSP00000320940.5, ENST00000348332.8

Conserved Domains (10) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:961 → 1359

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00989
Location:116 → 173

PAS; PAS fold

pfam07469
Location:1212 → 1268

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:924 → 970

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:632 → 708

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:741 → 818

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:468 → 590

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
NM_147223.3 → NP_671756.1 nuclear receptor coactivator 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as SRC1e, contains an additional segment in the coding region compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC013459, AC093798

Consensus CDS

CCDS1713.1

UniProtKB/TrEMBL

A8K1V4

Related

ENSP00000288599.5, ENST00000288599.9

Conserved Domains (9) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07469
Location:1149 → 1205

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:924 → 970

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:632 → 708

SRC-1; Steroid receptor coactivator

pfam09606
Location:974 → 1309

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:741 → 818

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:468 → 590

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
NM_147233.2 → NP_671766.1 nuclear receptor coactivator 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as SRC(-Q), uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 3) that lacks a single amino acid, compared to isoform 1.

Source sequence(s)

AC013459, AJ000881, BE675986, BF975824, CB047008, U90661

Consensus CDS

CCDS42660.1

UniProtKB/TrEMBL

A8K1V4

Related

ENSP00000379197.3, ENST00000395856.3

Conserved Domains (10) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:961 → 1359

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00989
Location:116 → 173

PAS; PAS fold

pfam07469
Location:1212 → 1268

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:924 → 970

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:632 → 708

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:741 → 818

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:468 → 590

NCOA_u2; Unstructured region on nuclear receptor coactivator protein