U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DKK3 dickkopf WNT signaling pathway inhibitor 3 [ Homo sapiens (human) ]

    Gene ID: 27122, updated on 28-Oct-2024

    Summary

    Official Symbol
    DKK3provided by HGNC
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 3provided by HGNC
    Primary source
    HGNC:HGNC:2893
    See related
    Ensembl:ENSG00000050165 MIM:605416; AllianceGenome:HGNC:2893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIG; CRRL; REIC
    Summary
    This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in heart (RPKM 451.8), brain (RPKM 155.8) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DKK3 in Genome Data Viewer
    Location:
    11p15.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (11963036..12009745, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (12054919..12101206, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11984583..12030883, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984311 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:11862595-11863460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:11863461-11864324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4461 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11892436-11893242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11893243-11894047 Neighboring gene H3 histone pseudogene 33 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11989412-11990036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11990037-11990660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11990661-11991284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11991285-11991908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11997959-11998520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11998521-11999082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12028425-12029360 Neighboring gene long intergenic non-protein coding RNA 2547 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:12087483-12088682 Neighboring gene long intergenic non-protein coding RNA 2989

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables co-receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dickkopf-related protein 3
    Names
    RIG-like 5-6
    RIG-like 7-1
    cardiomyocyte regeneration-related lncRNA
    dickkopf 3 homolog
    dickkopf homolog 3
    dickkopf-3
    dkk-3
    hDkk-3
    regulated in glioma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018057.2NP_001018067.1  dickkopf-related protein 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001018067.1

      Status: REVIEWED

      Source sequence(s)
      AL535720, BC007660, BQ690088, H18461
      Consensus CDS
      CCDS7808.1
      UniProtKB/Swiss-Prot
      A8K1I2, D3DQW1, Q9UBP4, Q9ULB7
      UniProtKB/TrEMBL
      Q6PQ81
      Related
      ENSP00000506835.1, ENST00000683431.1
      Conserved Domains (2) summary
      pfam06607
      Location:208273
      Prokineticin; Prokineticin
      pfam04706
      Location:147196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    2. NM_001330220.3NP_001317149.1  dickkopf-related protein 3 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AB057591, AC124276, BF724383, BQ894810
      Consensus CDS
      CCDS81555.1
      UniProtKB/TrEMBL
      B4DID6, F6SYF8
    3. NM_013253.5NP_037385.2  dickkopf-related protein 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_037385.2

      Status: REVIEWED

      Source sequence(s)
      AB057591, BC007660, BQ690088, H18461
      Consensus CDS
      CCDS7808.1
      UniProtKB/Swiss-Prot
      A8K1I2, D3DQW1, Q9UBP4, Q9ULB7
      UniProtKB/TrEMBL
      Q6PQ81
      Related
      ENSP00000314910.4, ENST00000326932.8
      Conserved Domains (2) summary
      pfam06607
      Location:208273
      Prokineticin; Prokineticin
      pfam04706
      Location:147196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    4. NM_015881.6NP_056965.3  dickkopf-related protein 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_056965.3

      Status: REVIEWED

      Source sequence(s)
      AC124276, BC007660, BQ690088, CB156451, H18461
      Consensus CDS
      CCDS7808.1
      UniProtKB/Swiss-Prot
      A8K1I2, D3DQW1, Q9UBP4, Q9ULB7
      UniProtKB/TrEMBL
      Q6PQ81
      Related
      ENSP00000379762.2, ENST00000396505.7
      Conserved Domains (2) summary
      pfam06607
      Location:208273
      Prokineticin; Prokineticin
      pfam04706
      Location:147196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      11963036..12009745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426775.1XP_047282731.1  dickkopf-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A8K1I2, D3DQW1, Q9UBP4, Q9ULB7
    2. XM_047426774.1XP_047282730.1  dickkopf-related protein 3 isoform X1

      UniProtKB/TrEMBL
      F6SYF8
      Related
      ENSP00000433112.1, ENST00000525493.5
    3. XM_006718178.3XP_006718241.1  dickkopf-related protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006718241.1

      UniProtKB/Swiss-Prot
      A8K1I2, D3DQW1, Q9UBP4, Q9ULB7
      UniProtKB/TrEMBL
      Q6PQ81
      Conserved Domains (2) summary
      pfam06607
      Location:208273
      Prokineticin; Prokineticin
      pfam04706
      Location:147196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    4. XM_017017555.2XP_016873044.1  dickkopf-related protein 3 isoform X1

      UniProtKB/TrEMBL
      B4DID6, F6SYF8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      12054919..12101206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)