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    P3H2 prolyl 3-hydroxylase 2 [ Gallus gallus (chicken) ]

    Gene ID: 414143, updated on 10-Oct-2024

    Summary

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    Symbol
    P3H2provided by CGNC
    Full Name
    prolyl 3-hydroxylase 2provided by CGNC
    Primary source
    CGNC:49910
    See related
    Ensembl:ENSGALG00010017579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    LEPREL1
    Orthologs
    human mouse all
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    Genomic context

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    See P3H2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (13662975..13735547)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (13475876..13531079)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene claudin 16 Neighboring gene claudin 1 Neighboring gene uncharacterized LOC121111464 Neighboring gene tumor protein p63 Neighboring gene uncharacterized LOC101751159

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens. Fernandes RJ, et al. J Biol Chem, 2011 Sep 2. PMID 21757687, Free PMC Article
    2. Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes. Vranka JA, et al. J Biol Chem, 2004 May 28. PMID 15044469
    3. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables procollagen-proline 3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 3-hydroxylase 2
    Names
    leprecan-like 1
    leprecan-like protein 1
    NP_001001530.2
    NP_001385380.1
    XP_015146870.2
    XP_040561423.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001530.2 → NP_001001530.2  prolyl 3-hydroxylase 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      UniProtKB/TrEMBL
      A0A8V0YVA2
      Related
      ENSGALP00010024988.1, ENSGALT00010042498.1

    2. NM_001398451.1 → NP_001385380.1  prolyl 3-hydroxylase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      Conserved Domains (1) summary
      smart00702
      Location:295 → 493
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      13662975..13735547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040705489.2 → XP_040561423.1  prolyl 3-hydroxylase 2 isoform X2

      Conserved Domains (1) summary
      smart00702
      Location:321 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_015291384.4 → XP_015146870.2  prolyl 3-hydroxylase 2 isoform X1

      Conserved Domains (1) summary
      cl21496
      Location:458 → 545
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      13475876..13531079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6JHU7.1 GenPept UniProtKB/Swiss-Prot:Q6JHU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.