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    BCL6 B-cell CLL/lymphoma 6 [ Gallus gallus (chicken) ]

    Gene ID: 424912, updated on 17-Aug-2024

    Summary

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    Symbol
    BCL6provided by CGNC
    Full Name
    B-cell CLL/lymphoma 6provided by CGNC
    Primary source
    CGNC:5559
    See related
    Ensembl:ENSGALG00010013635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See BCL6 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (14479373..14495601)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (14275276..14291508)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101751200 Neighboring gene uncharacterized LOC107054097 Neighboring gene somatostatin 1 Neighboring gene mannan binding lectin serine peptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation. Alinikula J, et al. Eur J Immunol, 2011 Aug. PMID 21674482
    2. Bcl6 is a transcriptional repressor for the IL-18 gene. Takeda N, et al. J Immunol, 2003 Jul 1. PMID 12817026
    3. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Walker SR, et al. Oncogene, 2007 Jan 11. PMID 16819511
    4. Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcepsilonRI/IgE cross-linking. Ohtsuka Y, et al. Mol Immunol, 2005 Aug. PMID 15950739
    5. Testicular germ cell apoptosis in Bcl6-deficient mice. Kojima S, et al. Development, 2001 Jan. PMID 11092811

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-cell lymphoma 6 protein homolog
    Names
    B-cell CLL/lymphoma 6 (zinc finger protein 51)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012930.1 → NP_001012948.1  B-cell lymphoma 6 protein homolog

      See identical proteins and their annotated locations for NP_001012948.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ719545
      UniProtKB/Swiss-Prot
      Q5ZM39
      Related
      ENSGALP00010019424.1, ENSGALT00010032792.1
      Conserved Domains (4) summary
      smart00225
      Location:33 → 129
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:578 → 598
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:590 → 615
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      14479373..14495601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015291406.4 → XP_015146892.2  B-cell lymphoma 6 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN89
      Conserved Domains (3) summary
      COG5189
      Location:545 → 650
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:578 → 598
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18331
      Location:8 → 125
      BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

    2. XM_040705572.2 → XP_040561506.1  B-cell lymphoma 6 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN89
      Conserved Domains (3) summary
      COG5189
      Location:545 → 650
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:578 → 598
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18331
      Location:8 → 125
      BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

    3. XM_025153369.3 → XP_025009137.2  B-cell lymphoma 6 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN89
      Conserved Domains (3) summary
      COG5189
      Location:545 → 650
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:578 → 598
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18331
      Location:8 → 125
      BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      14275276..14291508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046923881.1 → XP_046779837.1  B-cell lymphoma 6 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN89

    2. XM_046923883.1 → XP_046779839.1  B-cell lymphoma 6 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN89

    3. XM_046923882.1 → XP_046779838.1  B-cell lymphoma 6 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN89
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZM39.1 GenPept UniProtKB/Swiss-Prot:Q5ZM39

    Gene LinkOut

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    Research Materials