CDH1 cadherin 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CDH1provided by CGNC
Full Name: cadherin 1provided by CGNC
Primary source: CGNC:377
See related: Ensembl:ENSGALG00010010422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: cadherin-1
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Genomic context

Location:: chromosome: 11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	11	NC_052542.1 (18517669..18526385)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	11	NC_052583.1 (18865659..18874368)

Chromosome 11 - NC_052542.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we demonstrate that the balance of Ecad and Ncad is dependent upon the availability of beta-catenin proteins, and that alteration of either classical cadherin modifies the proportions of the neural crest and neuroectodermal cells that are specified
Title: A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices.
These results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors.
Title: Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
E-cadherin, cytokeratin and alpha-smooth muscle actin were localized in chicken ovarian cancer cells by immunostaining.
Title: Characterization of ascites-derived ovarian tumor cells from spontaneously occurring ovarian tumors of the chicken: evidence for E-cadherin upregulation.
These results reveal one of the mechanisms whereby molecular cross talk between cadherins and integrins upregulates traction forces at cell-fibronectin adhesion sites.
Title: E-cadherin-dependent stimulation of traction force at focal adhesions via the Src and PI3K signaling pathways.
Data found that deployment of the E- to N-cadherin switch program varies considerably along the embryonic axis.
Title: Timing and kinetics of E- to N-cadherin switch during neurulation in the avian embryo.
E-cadherin expression is decreased by gonadotropin treatments in the ovary of chicken embryo.
Title: Gonadotropins regulate cadherin expression in the ovary of the chicken embryo (Gallus gallus).
Retinoic acid promotes proliferation of chicken primordial germ cells by increased expression of E-cadherin and alpha2/beta catenins.
Title: The promoting effect of retinoic acid on proliferation of chicken primordial germ cells by increased expression of cadherin and catenins.
E-cadherin may prove to be an important target in the preventative treatment of metastatic ovarian cancer and further confirm that the laying hen is a good model for the study of human epithelial ovarian carcinoma.
Title: E-cadherin expression in ovarian cancer in the laying hen, Gallus domesticus, compared to human ovarian cancer.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell junction assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cadherin-1

Names: E-cadherin; L-CAM; cadherin 1, type 1, E-cadherin (epithelial); epithelial cadherin; liver cell adhesion molecule; liver cell adhesion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039258.3 → NP_001034347.3 cadherin-1 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000248

UniProtKB/TrEMBL

A0A8V0Y995

Related

ENSGALP00010014165.1, ENSGALT00010024941.1

Conserved Domains (3) summary

cd00031
Location:164 → 264

CA_like; Cadherin repeat-like domain

cd11304
Location:272 → 377

Cadherin_repeat; Cadherin tandem repeat domain

smart01055
Location:35 → 121

Cadherin_pro; Cadherin prodomain like

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

18517669..18526385

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015292581.4 → XP_015148067.2 cadherin-1 isoform X1

UniProtKB/TrEMBL

A0A8V0Y995

Conserved Domains (3) summary

cd00031
Location:164 → 264

CA_like; Cadherin repeat-like domain

cd11304
Location:272 → 377

Cadherin_repeat; Cadherin tandem repeat domain

smart01055
Location:35 → 121

Cadherin_pro; Cadherin prodomain like