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    TIMP3 TIMP metallopeptidase inhibitor 3 [ Gallus gallus (chicken) ]

    Gene ID: 396483, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TIMP3provided by CGNC
    Official Full Name
    TIMP metallopeptidase inhibitor 3provided by CGNC
    Primary source
    CGNC:9540
    See related
    Ensembl:ENSGALG00010015407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    IMP-3; TIMP-3
    Orthologs
    human mouse all
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    Genomic context

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    See TIMP3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (53137054..53174022, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (53426398..53463345, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053589 Neighboring gene LARGE xylosyl- and glucuronyltransferase 1 Neighboring gene synapsin III Neighboring gene uncharacterized LOC107053588 Neighboring gene F-box protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 21-kDa protein is a transformation-sensitive metalloproteinase inhibitor of chicken fibroblasts. Staskus PW, et al. J Biol Chem, 1991 Jan 5. PMID 1845973
    2. A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family. Pavloff N, et al. J Biol Chem, 1992 Aug 25. PMID 1512267
    3. Mapping the ABCA4, IMPDH2 and TIMP3 genes in chicken. Paton IR, et al. Anim Genet, 2003 Oct. PMID 14510686
    4. Involvement of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct regression and recrudescence. Leśniak-Walentyn A, et al. Cell Tissue Res, 2016 Nov. PMID 27342592
    5. Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during maturation. Leśniak-Walentyn A, et al. Cell Tissue Res, 2016 Apr. PMID 26395636, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Real-time polymerase chain reaction and western blot revealed different expression of MMP-2, -7, -9 and TIMP-2 and -3 on mRNA and protein levels, respectively, as well as activity of MMP-2 and -9 by activity assay in the oviduct parts.
      Title: Involvement of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct regression and recrudescence.
    2. Protein level of MMP-9 was diminished, while MMP-7 and TIMP-3 were elevated in the oviduct of growing birds. MMP-2 and TIMP-2 protein levels remained constant, with a slight increase in MMP-2 concentration just before reaching maturity.
      Title: Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during maturation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to organic substance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metalloproteinase inhibitor 3
    Names
    21 kDa protein of extracellular matrix
    TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    tissue inhibitor of metalloproteinase 3
    tissue inhibitor of metalloproteinases 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205487.3 → NP_990818.1  metalloproteinase inhibitor 3 precursor

      See identical proteins and their annotated locations for NP_990818.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000012
      UniProtKB/Swiss-Prot
      P26652
      Related
      ENSGALP00010021525.1, ENSGALT00010037000.1
      Conserved Domains (1) summary
      cd03585
      Location:25 → 201
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      53137054..53174022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      53426398..53463345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26652.2 GenPept UniProtKB/Swiss-Prot:P26652

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.