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    C6orf141 chromosome 6 open reading frame 141 [ Homo sapiens (human) ]

    Gene ID: 135398, updated on 28-Oct-2024

    Summary

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    Official Symbol
    C6orf141provided by HGNC
    Official Full Name
    chromosome 6 open reading frame 141provided by HGNC
    Primary source
    HGNC:HGNC:21351
    See related
    Ensembl:ENSG00000197261 AllianceGenome:HGNC:21351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to act upstream of or within blastocyst hatching. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in gall bladder (RPKM 5.1), duodenum (RPKM 3.8) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C6orf141 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49550668..49561916)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49392796..49404015)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49518381..49529629)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:49431050-49431949 Neighboring gene centromere protein Q Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49450846-49451350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49451351-49451854 Neighboring gene glycine-N-acyltransferase like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24664 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49519182-49519701 Neighboring gene Sharpr-MPRA regulatory region 6456 Neighboring gene cytochrome P450 family 2 subfamily AC member 1, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr6:49553494-49553995 Neighboring gene MPRA-validated peak5837 silencer Neighboring gene Rh associated glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer. Yang CM, et al. Sci Rep, 2019 Mar 14. PMID 30872783, Free PMC Article
    2. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
    3. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
    4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer.
      Title: Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46457

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein C6orf141

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145652.2 → NP_001139124.2  uncharacterized protein C6orf141

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AL590244
      Consensus CDS
      CCDS55018.1
      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1
      Related
      ENSP00000434602.2, ENST00000529246.4

    RNA

    1. NR_146853.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    2. NR_146854.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    3. NR_146855.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    4. NR_146856.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    5. NR_146857.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    6. NR_146858.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    7. NR_146859.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    8. NR_146860.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    9. NR_146861.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    10. NR_146862.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    11. NR_146863.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    12. NR_146864.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    13. NR_170563.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    14. NR_170564.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    15. NR_170565.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    16. NR_170566.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    17. NR_170567.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    18. NR_170568.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    19. NR_170569.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    20. NR_170570.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    21. NR_170571.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    22. NR_170572.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    23. NR_170573.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    24. NR_170574.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    25. NR_170575.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    26. NR_170576.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    27. NR_170577.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    28. NR_170578.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    29. NR_170579.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    30. NR_170580.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    31. NR_170581.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    32. NR_170582.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    33. NR_170583.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    34. NR_170584.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    35. NR_170585.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    36. NR_170586.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    37. NR_170587.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    38. NR_170588.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    39. NR_170589.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    40. NR_170590.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    41. NR_170591.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    42. NR_170592.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    43. NR_170593.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590244

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      49550668..49561916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418229.1 → XP_047274185.1  uncharacterized protein C6orf141 isoform X1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    2. XM_047418226.1 → XP_047274182.1  uncharacterized protein C6orf141 isoform X1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    3. XM_047418230.1 → XP_047274186.1  uncharacterized protein C6orf141 isoform X1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1
      Related
      ENSP00000436754.1, ENST00000414696.5

    4. XM_047418225.1 → XP_047274181.1  uncharacterized protein C6orf141 isoform X1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    5. XM_005248850.4 → XP_005248907.1  uncharacterized protein C6orf141 isoform X1

      See identical proteins and their annotated locations for XP_005248907.1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    6. XM_047418227.1 → XP_047274183.1  uncharacterized protein C6orf141 isoform X1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    7. XM_047418231.1 → XP_047274187.1  uncharacterized protein C6orf141 isoform X1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    8. XM_006714997.3 → XP_006715060.1  uncharacterized protein C6orf141 isoform X1

      See identical proteins and their annotated locations for XP_006715060.1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    9. XM_047418228.1 → XP_047274184.1  uncharacterized protein C6orf141 isoform X1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1
      Related
      ENSP00000431184.1, ENST00000371194.7

    10. XM_005248853.3 → XP_005248910.1  uncharacterized protein C6orf141 isoform X1

      See identical proteins and their annotated locations for XP_005248910.1

      UniProtKB/Swiss-Prot
      A8K1H4, Q5SZD1, Q8N400, Q96NQ1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      49392796..49404015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354322.1 → XP_054210297.1  uncharacterized protein C6orf141 isoform X1

    2. XM_054354324.1 → XP_054210299.1  uncharacterized protein C6orf141 isoform X1

    3. XM_054354327.1 → XP_054210302.1  uncharacterized protein C6orf141 isoform X1

    4. XM_054354321.1 → XP_054210296.1  uncharacterized protein C6orf141 isoform X1

    5. XM_054354319.1 → XP_054210294.1  uncharacterized protein C6orf141 isoform X1

    6. XM_054354326.1 → XP_054210301.1  uncharacterized protein C6orf141 isoform X1

    7. XM_054354325.1 → XP_054210300.1  uncharacterized protein C6orf141 isoform X1

    8. XM_054354318.1 → XP_054210293.1  uncharacterized protein C6orf141 isoform X1

    9. XM_054354316.1 → XP_054210291.1  uncharacterized protein C6orf141 isoform X1

    10. XM_054354317.1 → XP_054210292.1  uncharacterized protein C6orf141 isoform X1

    11. XM_054354320.1 → XP_054210295.1  uncharacterized protein C6orf141 isoform X1

    12. XM_054354323.1 → XP_054210298.1  uncharacterized protein C6orf141 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153344.1: Suppressed sequence

      Description
      NM_153344.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SZD1.3 GenPept UniProtKB/Swiss-Prot:Q5SZD1

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