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    Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 [ Mus musculus (house mouse) ]

    Gene ID: 11504, updated on 2-Nov-2024

    Summary

    Official Symbol
    Adamts1provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 1provided by MGI
    Primary source
    MGI:MGI:109249
    See related
    Ensembl:ENSMUSG00000022893 AllianceGenome:MGI:109249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1
    Summary
    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]
    Expression
    Broad expression in lung adult (RPKM 22.1), subcutaneous fat pad adult (RPKM 15.6) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adamts1 in Genome Data Viewer
    Location:
    16 C3.3; 16 48.2 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (85590715..85600001, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (85793827..85803113, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52244 Neighboring gene STARR-seq mESC enhancer starr_41383 Neighboring gene STARR-seq mESC enhancer starr_41384 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41385 Neighboring gene STARR-seq mESC enhancer starr_41386 Neighboring gene STARR-seq mESC enhancer starr_41388 Neighboring gene STARR-seq mESC enhancer starr_41389 Neighboring gene RIKEN cDNA 4930556C24 gene Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 5 Neighboring gene STARR-seq mESC enhancer starr_41390 Neighboring gene predicted gene, 46558

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 1
    Names
    ADAM-TS 1
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
    NP_033751.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009621.5NP_033751.3  A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

      See identical proteins and their annotated locations for NP_033751.3

      Status: REVIEWED

      Source sequence(s)
      AC126936, AK161409, AK163622, BP764139, CF738767
      Consensus CDS
      CCDS28287.1
      UniProtKB/Swiss-Prot
      E9QMN9, O54768, P97857
      UniProtKB/TrEMBL
      Q3U0I4
      Related
      ENSMUSP00000023610.9, ENSMUST00000023610.15
      Conserved Domains (6) summary
      smart00209
      Location:563615
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:259464
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:259468
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70194
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:726843
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:469549
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      85590715..85600001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)