MIR616 microRNA 616 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR616provided by HGNC
Official Full Name: microRNA 616provided by HGNC
Primary source: HGNC:HGNC:32872
See related: Ensembl:ENSG00000208028 MIM:614489; miRBase:MI0003629; AllianceGenome:HGNC:32872
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN616; hsa-mir-616
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 12q13.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (57519163..57519259, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (57487391..57487487, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (57912946..57913042, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-616-3p alleviates inflammatory response by targeting C-X-C motif chemokine ligand 5.
Title: miR-616-3p alleviates inflammatory response by targeting C-X-C motif chemokine ligand 5.
circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis.
Title: circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis.
UPR-Induced miR-616 Inhibits Human Breast Cancer Cell Growth and Migration by Targeting c-MYC.
Title: UPR-Induced miR-616 Inhibits Human Breast Cancer Cell Growth and Migration by Targeting c-MYC.
MiR-616 promotes the progression of pancreatic carcinoma by targeting OXR1.
Title: MiR-616 promotes the progression of pancreatic carcinoma by targeting OXR1.
LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
Title: LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs.
Title: Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs.
Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway.
Title: Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway.
MicroRNAs Affect Complement Regulator Expression and Mitochondrial Activity to Modulate Cell Resistance to Complement-Dependent Cytotoxicity.
Title: MicroRNAs Affect Complement Regulator Expression and Mitochondrial Activity to Modulate Cell Resistance to Complement-Dependent Cytotoxicity.
miR-576, miR-616 and miR-133a-2 are three newly discovered biomarkers of renal cell carcinoma in this study.
Title: Computational identification and analysis of early diagnostic biomarkers for kidney cancer.
Mechanistic investigations demonstrated that TUSC7 can interact with miR-616 and decrease its expression, thereby upregulating the expression of miR-616's targets SOCS4 (SOCS5).
Title: Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.