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    Lrrc3 leucine rich repeat containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246773, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrrc3provided by RGD
    Official Full Name
    leucine rich repeat containing 3provided by RGD
    Primary source
    RGD:628861
    See related
    EnsemblRapid:ENSRNOG00000001217 AllianceGenome:RGD:628861
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be active in plasma membrane. Orthologous to human LRRC3 (leucine rich repeat containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 14.6), Lung (RPKM 12.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10758399..10763358)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10758919..10763736)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11488514..11491354)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 2 Neighboring gene Z6 small nucleolar RNA Neighboring gene Z6 small nucleolar RNA Neighboring gene thrombospondin-type laminin G domain and EAR repeats Neighboring gene keratin associated protein 10-8 like 1 Neighboring gene keratin associated protein 10 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145679.1 → NP_663712.1  leucine-rich repeat-containing protein 3 precursor

      See identical proteins and their annotated locations for NP_663712.1

      Status: PROVISIONAL

      Source sequence(s)
      AB086432
      UniProtKB/Swiss-Prot
      P59035
      UniProtKB/TrEMBL
      A6JK58
      Related
      ENSRNOP00000108056.1, ENSRNOT00000131414.1
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:48 → 65
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10758399..10763358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256240.4 → XP_006256302.1  leucine-rich repeat-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006256302.1

      UniProtKB/Swiss-Prot
      P59035
      UniProtKB/TrEMBL
      A6JK58
      Related
      ENSRNOP00000001632.2, ENSRNOT00000001632.5
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:48 → 65
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59035.1 GenPept UniProtKB/Swiss-Prot:P59035

    Gene LinkOut

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