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    WDR89 WD repeat domain 89 [ Homo sapiens (human) ]

    Gene ID: 112840, updated on 2-Nov-2024

    Summary

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    Official Symbol
    WDR89provided by HGNC
    Official Full Name
    WD repeat domain 89provided by HGNC
    Primary source
    HGNC:HGNC:20489
    See related
    Ensembl:ENSG00000140006 AllianceGenome:HGNC:20489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSTP050; C14orf150
    Summary
    Predicted to act upstream of or within corpus callosum development and ventricular system development. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 4.5), thyroid (RPKM 4.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WDR89 in Genome Data Viewer
    Location:
    14q23.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (63597039..63641871, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (57804429..57849265, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64063757..64108589, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 5 Neighboring gene glycine C-acetyltransferase pseudogene 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 2 Neighboring gene RNA, U6 small nuclear 597, pseudogene Neighboring gene RNA, U6 small nuclear 1162, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64108177-64108836 Neighboring gene uncharacterized LOC105370532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8513 Neighboring gene uncharacterized LOC124903437 Neighboring gene uncharacterized LOC124903439

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma. Zhou P, et al. Oncogene, 2023 Mar. PMID 36604567
    2. Nucleolar proteome dynamics. Andersen JS, et al. Nature, 2005 Jan 6. PMID 15635413
    3. WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. Caron P, et al. Genes Dev, 2019 Jun 1. PMID 31048545, Free PMC Article
    4. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Gordon DE, et al. Science, 2020 Dec 4. PMID 33060197, Free PMC Article
    5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9907

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in corpus callosum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ventricular system development IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 89

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008726.3 → NP_001008726.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_001008726.1

      Status: VALIDATED

      Source sequence(s)
      BC010698, BP278550, DA882425
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001258272.2 → NP_001245201.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_001245201.1

      Status: VALIDATED

      Source sequence(s)
      BC010698, BP278550, DA882425, DB178690
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Related
      ENSP00000267522.3, ENST00000267522.7
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001382423.1 → NP_001369352.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001382424.1 → NP_001369353.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_001382425.1 → NP_001369354.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. NM_001382426.1 → NP_001369355.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. NM_001382427.1 → NP_001369356.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. NM_001382428.1 → NP_001369357.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. NM_001382429.1 → NP_001369358.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. NM_080666.4 → NP_542397.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_542397.1

      Status: VALIDATED

      Source sequence(s)
      BC010698, DA882425
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Related
      ENSP00000480112.1, ENST00000620954.2
      Conserved Domains (2) summary
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      63597039..63641871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536383.3 → XP_011534685.1  WD repeat-containing protein 89 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:69 → 387
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:112 → 150
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:79 → 387
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      57804429..57849265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375310.1 → XP_054231285.1  WD repeat-containing protein 89 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FK6.1 GenPept UniProtKB/Swiss-Prot:Q96FK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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