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    Use1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 67023, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Use1provided by MGI
    Official Full Name
    unconventional SNARE in the ER 1 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1914273
    See related
    Ensembl:ENSMUSG00000002395 AllianceGenome:MGI:1914273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12; Ed2; p31; Q-snare; 2010315L10Rik; 5730403H22Rik
    Summary
    Predicted to enable SNAP receptor activity. Acts upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Predicted to be located in COPI-coated vesicle. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesoderm; optic vesicle; and primitive streak. Orthologous to human USE1 (unconventional SNARE in the ER 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 55.7), testis adult (RPKM 48.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Use1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71819329..71822376)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71366848..71369732)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adenine phosphoribosyl transferase, pseudogene Neighboring gene 4HAUS augmin-like complex, subunit 8 Neighboring gene STARR-positive B cell enhancer ABC_E1105 Neighboring gene myosin IXb Neighboring gene STARR-positive B cell enhancer ABC_E6650 Neighboring gene occludin/ELL domain containing 1 Neighboring gene nuclear receptor subfamily 2, group F, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. mED2--a novel gene involved in mouse embryonic development. Duan JZ, et al. Yi Chuan Xue Bao, 2006 Aug. PMID 16939003
    2. Sec22b is a negative regulator of phagocytosis in macrophages. Hatsuzawa K, et al. Mol Biol Cell, 2009 Oct. PMID 19710423, Free PMC Article
    3. Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment. Nieradka A, et al. PLoS One, 2014. PMID 25184340, Free PMC Article
    4. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Uemura T, et al. Mol Cell Biol, 2009 Apr. PMID 19188447, Free PMC Article
    5. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Lee PC, et al. Mol Cell, 2013 Apr 25. PMID 23499007, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site.
      Title: Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.
    2. Uba6 and Use1 promote proteasomal turnover of Ube3a in mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation in vitro.
      Title: Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.
    3. Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis.
      Title: Sec22b is a negative regulator of phagocytosis in macrophages.
    4. p31 is an essential molecule involved in the maintenance of endoplasmic reticulum (ER) morphology and that its deficiency leads to ER stress-induced apoptosis.
      Title: p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum tubular network organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of ER to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in COPI-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vesicle transport protein USE1
    Names
    USE1-like protein
    embryonic development factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145780.1 → NP_001139252.1  vesicle transport protein USE1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate translational start codon, compared to variant 1. The encoded isoform (3) is longer at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BC075695, BY097923
      Consensus CDS
      CCDS52582.1
      UniProtKB/TrEMBL
      E9Q496, Q5I940
      Related
      ENSMUSP00000105680.3, ENSMUST00000110053.9
      Conserved Domains (1) summary
      pfam09753
      Location:31 → 280
      Use1; Membrane fusion protein Use1

    2. NM_025917.4 → NP_080193.1  vesicle transport protein USE1 isoform 1

      See identical proteins and their annotated locations for NP_080193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK160726, BC075695, BY286283
      Consensus CDS
      CCDS22390.1
      UniProtKB/Swiss-Prot
      Q3TUK0, Q80V73, Q99MB6, Q9CQ56
      UniProtKB/TrEMBL
      Q5I940
      Related
      ENSMUSP00000019169.8, ENSMUST00000019169.8
      Conserved Domains (1) summary
      pfam09753
      Location:17 → 266
      Use1; Membrane fusion protein Use1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71819329..71822376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154245.1 → XP_036010138.1  vesicle transport protein USE1 isoform X1

      UniProtKB/TrEMBL
      Q5I940
      Conserved Domains (1) summary
      pfam09753
      Location:73 → 324
      Use1; Membrane fusion protein Use1

    2. XM_036154246.1 → XP_036010139.1  vesicle transport protein USE1 isoform X2

      UniProtKB/TrEMBL
      Q5I940
      Conserved Domains (1) summary
      pfam09753
      Location:73 → 323
      Use1; Membrane fusion protein Use1

    3. XM_036154247.1 → XP_036010140.1  vesicle transport protein USE1 isoform X4

      UniProtKB/TrEMBL
      Q5I940
      Conserved Domains (1) summary
      pfam09753
      Location:16 → 267
      Use1; Membrane fusion protein Use1

    4. XM_006509726.2 → XP_006509789.1  vesicle transport protein USE1 isoform X3

      UniProtKB/TrEMBL
      Q5I940
      Conserved Domains (1) summary
      pfam09753
      Location:31 → 281
      Use1; Membrane fusion protein Use1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029768.3: Suppressed sequence

      Description
      NM_029768.3: This RefSeq was permanently suppressed because the CDS was partial and the transcript retained intronic sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ56.1 GenPept UniProtKB/Swiss-Prot:Q9CQ56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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