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    Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 76987, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hdhd2provided by MGI
    Official Full Name
    haloacid dehalogenase-like hydrolase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1924237
    See related
    Ensembl:ENSMUSG00000025421 AllianceGenome:MGI:1924237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610039H12Rik; 3110052N05Rik
    Summary
    Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be active in cytoplasm. Is expressed in cerebellum and cerebral cortex ventricular layer. Orthologous to human HDHD2 (haloacid dehalogenase like hydrolase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.2), frontal lobe adult (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hdhd2 in Genome Data Viewer
    Location:
    18 E3; 18 51.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77031775..77059867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (76944115..76972171)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45102 Neighboring gene predicted gene, 32058 Neighboring gene STARR-seq mESC enhancer starr_45103 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene predicted gene, 53183 Neighboring gene katanin p60 subunit A-like 2 Neighboring gene STARR-seq mESC enhancer starr_45107 Neighboring gene STARR-positive B cell enhancer mm9_chr18:77285922-77286223 Neighboring gene RIKEN cDNA 4930520E11 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Wang B, et al. Development, 2011 Oct. PMID 21937600, Free PMC Article
    2. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
    3. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    4. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Transposon induced (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    haloacid dehalogenase-like hydrolase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039201.2 → NP_001034290.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001034290.1

      Status: VALIDATED

      Source sequence(s)
      AC132608
      Consensus CDS
      CCDS37863.1
      UniProtKB/Swiss-Prot
      Q3U8M0, Q3UGR5, Q6PEB2, Q9CXN1, Q9DCF2
      Related
      ENSMUSP00000116243.2, ENSMUST00000148955.3
      Conserved Domains (1) summary
      cd07509
      Location:8 → 255
      HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

    2. NM_001039202.1 → NP_001034291.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001034291.1

      Status: VALIDATED

      Source sequence(s)
      AK152259, BY069367
      Consensus CDS
      CCDS37864.1
      UniProtKB/Swiss-Prot
      Q3UGR5
      Related
      ENSMUSP00000095128.5, ENSMUST00000097521.12
      Conserved Domains (1) summary
      pfam13344
      Location:10 → 86
      Hydrolase_6; Haloacid dehalogenase-like hydrolase

    3. NM_001361227.1 → NP_001348156.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132608
      Consensus CDS
      CCDS37863.1
      UniProtKB/Swiss-Prot
      Q3U8M0, Q3UGR5, Q6PEB2, Q9CXN1, Q9DCF2
      Related
      ENSMUSP00000114212.2, ENSMUST00000150990.9
      Conserved Domains (1) summary
      cd07509
      Location:8 → 255
      HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

    4. NM_029826.2 → NP_084102.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_084102.1

      Status: VALIDATED

      Source sequence(s)
      AC132608, AK137285, BY069367
      Consensus CDS
      CCDS37863.1
      UniProtKB/Swiss-Prot
      Q3U8M0, Q3UGR5, Q6PEB2, Q9CXN1, Q9DCF2
      Related
      ENSMUSP00000095129.4, ENSMUST00000097522.11
      Conserved Domains (1) summary
      cd07509
      Location:8 → 255
      HAD_PPase; inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      77031775..77059867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161307.1 → XP_036017200.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      cl21460
      Location:8 → 133
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. XM_036161308.1 → XP_036017201.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      cl21460
      Location:8 → 133
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UGR5.2 GenPept UniProtKB/Swiss-Prot:Q3UGR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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