PLAAT4 phospholipase A and acyltransferase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLAAT4provided by HGNC
Official Full Name: phospholipase A and acyltransferase 4provided by HGNC
Primary source: HGNC:HGNC:9869
See related: Ensembl:ENSG00000133321 MIM:605092; AllianceGenome:HGNC:9869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RIG1; TIG3; HRSL4; HRASLS4; PLAAT-4; RARRES3; PLA1/2-3
Summary: Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Annotation information: Note: RARRES3 (Gene ID: 5920) and DDX58 (Gene ID: 23586) share the RIG1/RIG-1 alias in common. RIG1 is a widely used alternative name for DExD/H-box helicase 58 (DDX58), which can be confused with the retinoic acid receptor responder 3 (RARRES3) gene, since they share the same alias. [22 Jan 2019]
Expression: Ubiquitous expression in small intestine (RPKM 43.2), duodenum (RPKM 36.6) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 11q12.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (63536808..63546458)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (63526070..63535720)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (63304280..63313930)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
Title: Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
we observed frameshift mutations of RARRES3 in 11 cases of colorectal cancer
Title: Mutational intratumoral heterogeneity of a putative tumor suppressor gene RARRES3 in colorectal cancers.
Identified the tumor suppressor RARRES3 as a critical target of G9a. Epigenetic silencing of RARRES3 contributed to the tumor-promoting function of G9a
Title: Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.
this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma
Title: High expression of TIG3 predicts poor survival in patients with primary glioblastoma.
Overexpression of TIG3 suppresses tumor growth in hepatocellular carcinoma
Title: The antitumor effect of TIG3 in liver cancer cells is involved in ERK1/2 inhibition.
Letter: Interleukin-22 inhibits tazarotene-induced gene 3 expression in keratinocytes via MAPK-ERK1/2 and JAK2/STAT3 signaling.
Title: Interleukin-22 inhibits tazarotene-induced gene 3 expression in HaCaT cells via MAPK-ERK1/2 and JAK2/STAT3 signaling.
findings provide a new insight into the molecular link between p53, protein acylation and Wnt/beta-catenin signaling whereby RARRES3 plays a pivotal role in modulating the acylation status of signaling proteins.
Title: Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells.
the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
Title: Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
RARRES3 downregulation engages metastasis-initiating capabilities by facilitating adhesion of the tumor cells to the lung parenchyma.
Title: RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation.
These findings argue that TIG3 is involved in the control of keratinocyte differentiation and that loss of TIG3 in transformed cells contributes to the malignant phenotype.
Title: TIG3: an important regulator of keratinocyte proliferation and survival.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH102234 (e-PCR)
- UniSTS:96568

PMC24531P1 (e-PCR)
- UniSTS:272259

PMC24531P2 (e-PCR)
- UniSTS:272260

PMC24531P3 (e-PCR)
- UniSTS:272261

STS-W47350 (e-PCR)
- UniSTS:83351

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	TAS Traceable Author Statement more info
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acylphosphatidylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acylphosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylethanolamine acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein-glutamine gamma-glutamyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase A and acyltransferase 4

Names: HRAS-like suppressor 4; RAR-responsive protein TIG3; phospholipase A/acyltransferase-4; retinoic acid receptor responder (tazarotene induced) 3; retinoic acid receptor responder 3; retinoic acid receptor responder protein 3; retinoic acid-inducible gene 1; retinoid-inducible gene 1 protein; tazarotene-induced gene 3 protein

NP_004576.2

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.