Mrgpra3 MAS-related GPR, member A3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrgpra3provided by MGI
Official Full Name: MAS-related GPR, member A3provided by MGI
Primary source: MGI:MGI:2684085
See related: Ensembl:ENSMUSG00000078698 AllianceGenome:MGI:2684085
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrga3
Summary: Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Acts upstream of or within chemosensory behavior. Located in axon and neuronal cell body membrane. Orthologous to several human genes including MRGPRX1 (MAS related GPR family member X1); MRGPRX2 (MAS related GPR family member X2); and MRGPRX3 (MAS related GPR family member X3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 7 B3; 7 30.91 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (47238698..47251120, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (47588950..47601372, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.
Title: Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.
Molecular Signature of Pruriceptive MrgprA3(+) Neurons.
Title: Molecular Signature of Pruriceptive MrgprA3(+) Neurons.
Results showed that the scratching bouts induced by chloroquine increased significantly under the acetone-ether-water (AEW) chronic pruritus; the density of MrgprA3 sensory fibers in the AEW-treated skin area and the number of MrgprA3 neurons in dorsal root ganglia from the AEW model mice also increased significantly. Further analysis showed that the MrgprA3 in mRNA level was also increased after AEW treatment.
Title: MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.
This study demonstrated that MrgprA3+ neurons have lower excitability than the same size MrgprA3--non-Dil and MrgprA3--Dil neurons. MrgprA3+ neurons exhibit decreased AP firing activity.
Title: Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.
showed that both MRGPRA3+ and MRGPRD+ neurons from hapten-challenged mice displayed a significantly more depolarized resting membrane potential, decreased rheobase, and greater number of action potentials at twice rheobase compared with neurons
Title: Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.
This study demonistrated that MrgprA3 expression defines a specific population of itch-mediating neurons and determined the molecular identity and cellular properties of these neurons.
Title: A subpopulation of nociceptors specifically linked to itch.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemosensory behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in response to chloroquine	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member A3

Names: G protein-coupled receptor MRGA3; Mas-related gene A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.