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    Acer3 alkaline ceramidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 66190, updated on 28-Oct-2024

    Summary

    Official Symbol
    Acer3provided by MGI
    Official Full Name
    alkaline ceramidase 3provided by MGI
    Primary source
    MGI:MGI:1913440
    See related
    Ensembl:ENSMUSG00000030760 AllianceGenome:MGI:1913440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phca; aPHC; 1110057L18Rik; 5430429L08Rik
    Summary
    Predicted to enable N-acylsphingosine amidohydrolase activity; calcium ion binding activity; and zinc ion binding activity. Involved in ceramide catabolic process; inflammatory response; and sphingosine biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in hair; integumental system; vibrissa; and vibrissa follicle. Orthologous to human ACER3 (alkaline ceramidase 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.7), liver E14 (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Acer3 in Genome Data Viewer
    Location:
    7 E1; 7 53.65 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97863015..97970415, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98213808..98321208, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene calpain 5 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105326664-105326964 Neighboring gene STARR-seq mESC enhancer starr_19624 Neighboring gene predicted gene, 16938 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 Neighboring gene STARR-seq mESC enhancer starr_19625 Neighboring gene STARR-seq mESC enhancer starr_19626 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105457877-105458178 Neighboring gene STARR-seq mESC enhancer starr_19627 Neighboring gene STARR-seq mESC enhancer starr_19628 Neighboring gene tsukushi, small leucine rich proteoglycan Neighboring gene predicted gene 44507

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acylsphingosine amidohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-acylsphingosine amidohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-acylsphingosine amidohydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ceramide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ceramide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phytosphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phytosphingosine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phytosphingosine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sphingosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sphingosine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingosine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alkaline ceramidase 3
    Names
    alkCDase 3
    alkaline CDase 3
    alkaline phytoceramidase
    phytoceramidase, alkaline
    NP_001347544.1
    NP_001347545.1
    NP_001347546.1
    NP_079684.2
    XP_030098749.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360615.1NP_001347544.1  alkaline ceramidase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC119880, AK017361
      Consensus CDS
      CCDS90274.1
      UniProtKB/TrEMBL
      D3YTU8
      Related
      ENSMUSP00000112884.2, ENSMUST00000120520.8
      Conserved Domains (1) summary
      pfam05875
      Location:1217
      Ceramidase; Ceramidase
    2. NM_001360616.1NP_001347545.1  alkaline ceramidase 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC111084, AC119880
      Conserved Domains (1) summary
      pfam05875
      Location:7156
      Ceramidase
    3. NM_001360617.1NP_001347546.1  alkaline ceramidase 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC111084, AC119880
      Conserved Domains (1) summary
      pfam05875
      Location:60149
      Ceramidase
    4. NM_025408.3NP_079684.2  alkaline ceramidase 3 isoform 1

      See identical proteins and their annotated locations for NP_079684.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC111084, AC119880
      Consensus CDS
      CCDS21468.1
      UniProtKB/Swiss-Prot
      Q542R2, Q9D099, Q9D0X4, Q9D3J4
      Related
      ENSMUSP00000033020.8, ENSMUST00000033020.14
      Conserved Domains (1) summary
      pfam05875
      Location:9259
      Ceramidase; Ceramidase

    RNA

    1. NR_153759.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC111084, AC119880

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97863015..97970415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242889.2XP_030098749.1  alkaline ceramidase 3 isoform X1

      Conserved Domains (1) summary
      pfam05875
      Location:4153
      Ceramidase

    RNA

    1. XR_004934168.1 RNA Sequence