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    Rasa4 RAS p21 protein activator 4 [ Mus musculus (house mouse) ]

    Gene ID: 54153, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rasa4provided by MGI
    Official Full Name
    RAS p21 protein activator 4provided by MGI
    Primary source
    MGI:MGI:1858600
    See related
    Ensembl:ENSMUSG00000004952 AllianceGenome:MGI:1858600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAPL; CAPRI
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Predicted to be located in cytosol. Predicted to colocalize with plasma membrane. Is expressed in trigeminal ganglion. Orthologous to several human genes including RASA4 (RAS p21 protein activator 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 17.6), spleen adult (RPKM 15.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasa4 in Genome Data Viewer
    Location:
    5 G2; 5 75.76 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136112775..136140714)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136083916..136111860)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene uroplakin 3B Neighboring gene uroplakin 3B-like Neighboring gene predicted gene, 40347 Neighboring gene STARR-positive B cell enhancer ABC_E2768 Neighboring gene STARR-seq mESC enhancer starr_14614 Neighboring gene microRNA 7035 Neighboring gene STARR-positive B cell enhancer ABC_E856 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide J Neighboring gene leucine-rich repeats and WD repeat domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6388

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Zhang J, et al. Nat Immunol, 2005 Sep. PMID 16041389, Free PMC Article
    2. CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane. Strazza M, et al. J Immunol, 2015 Mar 15. PMID 25637021
    3. Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding. Hikita A, et al. J Biol Chem, 2005 Dec 16. PMID 16234249
    4. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities. Dai Y, et al. J Biol Chem, 2011 Jun 3. PMID 21460216, Free PMC Article
    5. Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Thomas JW, et al. Genome Res, 2000 May. PMID 10810084, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that calcium-promoted Ras inactivator (CAPRI) C2AB domains are required for CD28 antigen inhibition of adhesion.
      Title: CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.
    2. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities
      Title: Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
    3. deltaCAPRI regulates RANKL shedding by modulating MMP14 expression through Ras signaling cascades other than the Erk pathway
      Title: Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0538

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein 4
    Names
    Ca2+promoted Ras inactivator
    calcium-promoted RAS inactivator
    rasGAP-activating-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039103.4 → NP_001034192.1  ras GTPase-activating protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001034192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC087420
      Consensus CDS
      CCDS39325.1
      UniProtKB/Swiss-Prot
      Q6PFQ7
      Related
      ENSMUSP00000098136.4, ENSMUST00000100570.10
      Conserved Domains (7) summary
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      smart00323
      Location:245 → 558
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13372
      Location:495 → 634
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00169
      Location:520 → 625
      PH; PH domain
      pfam00779
      Location:634 → 662
      BTK; BTK motif
      cl02569
      Location:264 → 503
      RasGAP; Ras GTPase Activating Domain
      cl14603
      Location:134 → 256
      C2; C2 domain

    2. NM_133914.4 → NP_598675.2  ras GTPase-activating protein 4 isoform 1

      See identical proteins and their annotated locations for NP_598675.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC087420
      Consensus CDS
      CCDS39324.1
      UniProtKB/Swiss-Prot
      Q2PMI6, Q3U2R4, Q571H1, Q58DY7, Q6PFQ7
      Related
      ENSMUSP00000037869.8, ENSMUST00000042135.14
      Conserved Domains (7) summary
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 549
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      smart00323
      Location:245 → 604
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13372
      Location:541 → 680
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00169
      Location:566 → 671
      PH; PH domain
      pfam00779
      Location:680 → 708
      BTK; BTK motif
      cl14603
      Location:134 → 256
      C2; C2 domain

    RNA

    1. NR_189324.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087420

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      136112775..136140714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165305.1 → XP_036021198.1  ras GTPase-activating protein 4 isoform X1

      Conserved Domains (3) summary
      pfam00779
      Location:330 → 358
      BTK; BTK motif
      cl02569
      Location:1 → 199
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:191 → 330
      PH-like; Pleckstrin homology-like domain

    2. XM_036165304.1 → XP_036021197.1  ras GTPase-activating protein 4 isoform X1

      Conserved Domains (3) summary
      pfam00779
      Location:330 → 358
      BTK; BTK motif
      cl02569
      Location:1 → 199
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:191 → 330
      PH-like; Pleckstrin homology-like domain

    3. XM_036165303.1 → XP_036021196.1  ras GTPase-activating protein 4 isoform X1

      Related
      ENSMUST00000135344.8
      Conserved Domains (3) summary
      pfam00779
      Location:330 → 358
      BTK; BTK motif
      cl02569
      Location:1 → 199
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:191 → 330
      PH-like; Pleckstrin homology-like domain

    4. XM_036165306.1 → XP_036021199.1  ras GTPase-activating protein 4 isoform X1

      Conserved Domains (3) summary
      pfam00779
      Location:330 → 358
      BTK; BTK motif
      cl02569
      Location:1 → 199
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:191 → 330
      PH-like; Pleckstrin homology-like domain

    5. XM_036165307.1 → XP_036021200.1  ras GTPase-activating protein 4 isoform X1

      Conserved Domains (3) summary
      pfam00779
      Location:330 → 358
      BTK; BTK motif
      cl02569
      Location:1 → 199
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:191 → 330
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_001784726.2 RNA Sequence

      Related
      ENSMUST00000134509.8

    2. XR_377106.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFQ7.1 GenPept UniProtKB/Swiss-Prot:Q6PFQ7

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