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    Ccndbp1 cyclin D-type binding-protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17151, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ccndbp1provided by MGI
    Official Full Name
    cyclin D-type binding-protein 1provided by MGI
    Primary source
    MGI:MGI:109595
    See related
    Ensembl:ENSMUSG00000023572 AllianceGenome:MGI:109595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIP1; GCIP; Maid; SECC-8; SSEC-8
    Summary
    Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human CCNDBP1 (cyclin D1 binding protein 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 18.2), bladder adult (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccndbp1 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120838925..120847374)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121008395..121016912)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene expressed sequence AV039307 Neighboring gene ubiquitin protein ligase E3 component n-recognin 1 Neighboring gene STARR-positive B cell enhancer ABC_E5971 Neighboring gene STARR-positive B cell enhancer ABC_E147 Neighboring gene transmembrane protein 62 Neighboring gene small nucleolar RNA, C/D box 3B, pseudogene 2 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ccndbp1 is a new positive regulator of skeletal myogenesis. Huang Y, et al. J Cell Sci, 2016 Jul 15. PMID 27235421
    2. Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice. Koyama K, et al. Sci Rep, 2024 Sep 10. PMID 39256539, Free PMC Article
    3. Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. Ma W, et al. Oncogene, 2006 Jul 13. PMID 16501603
    4. Maid is a negative regulator of transforming growth factor-β-induced cell migration. Motizuki M, et al. J Biochem, 2015 Nov. PMID 26002959
    5. Maid: a maternally transcribed novel gene encoding a potential negative regulator of bHLH proteins in the mouse egg and zygote. Hwang SY, et al. Dev Dyn, 1997 Jun. PMID 9186056

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice.
      Title: Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice.
    2. Ccndbp1 is a positive modulator of skeletal myogenic differentiation in vivo and in vitro.
      Title: Ccndbp1 is a new positive regulator of skeletal myogenesis.
    3. Data suggest Maid/Ccndbp1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); Maid does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis.
      Title: Maid is a negative regulator of transforming growth factor-β-induced cell migration.
    4. These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.
      Title: Maid (GCIP) is involved in cell cycle control of hepatocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-D1-binding protein 1
    Names
    grap2 and cyclin-D-interacting protein
    maternal Id-like protein
    maternal inhibition of differentiation
    stage specific embryonic cDNA-8 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355127.2 → NP_001342056.1  cyclin-D1-binding protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL844548
      UniProtKB/TrEMBL
      A0AA74IZC9
      Related
      ENSMUSP00000125961.4, ENSMUST00000171260.4
      Conserved Domains (1) summary
      pfam13324
      Location:52 → 305
      GCIP; Grap2 and cyclin-D-interacting

    2. NM_010761.3 → NP_034891.2  cyclin-D1-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_034891.2

      Status: VALIDATED

      Source sequence(s)
      AL844548
      Consensus CDS
      CCDS38213.1
      UniProtKB/Swiss-Prot
      Q3TVC7, Q3UMI3, Q61162, Q99JA7, Q99KG4
      UniProtKB/TrEMBL
      A0AA74IZC9
      Related
      ENSMUSP00000062496.9, ENSMUST00000060455.15
      Conserved Domains (1) summary
      pfam13324
      Location:52 → 316
      GCIP; Grap2 and cyclin-D-interacting

    RNA

    1. NR_185170.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844548

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120838925..120847374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239329.3 → XP_011237631.1  cyclin-D1-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam13324
      Location:1 → 133
      GCIP; Grap2 and cyclin-D-interacting
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TVC7.1 GenPept UniProtKB/Swiss-Prot:Q3TVC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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